表 3.
GAgP患者9个基因13个SNPs位点不同基因型与牙根形态异常
Different genotypes of 13 single nucleotide polymorphisms from 9 candidate genes and root morphology abnormalities in patients with GAgP
| SNPs | Gene type | GAgP, n(%) | Cone-rooted teeth of anterior | Teeth of root abnormalities | |||
| Median(P25, P75) | P | x±s/Median(P25, P75) | P | ||||
| VDR, vitamin D receptor; CTR, calcitotin receptor; MMP-8, matrix metallopeptidase 8; RANK, activator of NF-κB; DBP, vitamin D binding protein; EGF, epidermal growth factor; BMP2, bone morphogenetic protein 2; S100A8, calprotectin S100A8; Runx2/Cbfa1, core binding factor α1; SNPs, single nucleotide polymorphisms; GAgP, generalized aggressive periodontitis. | |||||||
| VDR rs2228570 | CC | 59 (33.91) | 0 (0，2) | 4.66±4.10 | |||
| CT | 90 (51.72) | 0 (0，2) | 0.02 | 3.71±3.93 | 0.01 | ||
| TT | 25 (14.37) | 0 (0，0) | 2.68±2.68 | ||||
| CTR rs2283002 | TT | 22 (13.25) | 0 (0，1.25) | 3.05±3.12 | |||
| CT | 95 (57.23) | 0 (0，2) | 0.14 | 3.43±3.95 | 0.03 | ||
| CC | 49 (29.52) | 0 (0，2.50) | 5.02±3.70 | ||||
| CTR rs2374634 | TT | 144 (83.72) | 0 (0，2) | 3 (0，6.75) | |||
| TC | 25 (14.53) | 0 (0，1) | 0.44 | 4 (0，5) | 0.75 | ||
| CC | 3 (1.74) | 0 (0，1) | 6 (0，7) | ||||
| MMP-8 rs11225395 | GG | 73 (41.01) | 0 (0，2) | 4.25±3.95 | |||
| AG | 88 (49.44) | 0 (0，1) | 0.23 | 3.48±3.70 | 0.38 | ||
| AA | 17 (9.55) | 0 (0，3) | 4.41±4.18 | ||||
| RANK rs11664594 | TT | 59 (34.30) | 0 (0，2) | 4.17±4.26 | |||
| AT | 87 (50.58) | 0 (0，2) | 0.80 | 4.18±3.80 | 0.21 | ||
| AA | 26 (15.12) | 0 (0，2) | 2.73±2.86 | ||||
| DBP rs17467825 | AA | 77 (44.77) | 0 (0，2) | 3.84±3.79 | |||
| AG | 73 (42.44) | 0 (0，2) | 0.72 | 3.67±3.62 | 0.45 | ||
| GG | 22 (12.79) | 0 (0，2.50) | 4.86±4.95 | ||||
| DBP rs4588 | CC | 76 (43.18) | 0 (0，2) | 3 (0.25，6) | |||
| CA | 79 (44.89) | 0 (0，2) | 0.51 | 4 (0，6) | 0.93 | ||
| AA | 21 (11.93) | 0 (0，3) | 2 (0，8.50) | ||||
| DBP rs7041 | TT | 97 (55.43) | 0 (0，2) | 3.84±3.60 | |||
| GT | 68 (38.86) | 0 (0，2) | 0.39 | 3.99±4.23 | 0.75 | ||
| GG | 10 (5.71) | 1.5 (0，2.50) | 4.80±3.82 | ||||
| EGF rs2237051 | AA | 73 (41.71) | 0 (0，1) | 3.89±4.06 | |||
| GA | 90 (51.43) | 0 (0，2) | 0.12 | 4.01±3.67 | 0.98 | ||
| GG | 12 (6.86) | 0 (0，2) | 3.83±4.28 | ||||
| BMP2 rs2273073 | TT | 156 (90.17) | 0 (0，2) | 0.81 | 3.96±3.83 | 0.97 | |
| GT | 17 (9.83) | 0 (0，2) | 4.00±4.26 | ||||
| GG | - | - | - | - | - | ||
| S100A8 rs3795391 | TT | 136 (77.27) | 0 (0，2) | 0.76 | 3.91±3.98 | 0.99 | |
| TC | 40 (22.73) | 0 (0，2) | 3.90±3.46 | ||||
| CC | - | - | - | - | - | ||
| S100A8 rs3806232 | TT | 130 (73.03) | 0 (0，2) | 0.41 | 3.79±4.00 | 0.63 | |
| CT | 48 (26.97) | 0 (0，2) | 4.10±3.47 | ||||
| CC | - | - | - | - | - | ||
| Runx2/Cbfa1 | CC | 87 (49.71) | 0 (0，2) | 3.44±3.73 | |||
| rs6938177 | TC | 71 (40.57) | 0 (0，3) | 0.01 | 4.65±4.03 | 0.041 | |
| TT | 17 (9.71) | 0 (0，0.50) | 2.47±2.62 | ||||