表 4.

GAgP患者9个基因13个SNPs位点不同基因型根形态异常发生率

Incidence of root morphological abnormalities in different genotypes of 13 single nucleotide polymorphisms from 9 candidate genes

SNPs	Gene type	Total	Incidence of root abnormality
			n(%)	Adjusted OR(95%CI)
VDR，vitamin D receptor; CTR，calcitotin receptor; MMP-8, matrix metallopeptidase 8; RANK, activator of NF-κB; DBP, vitamin D binding protein; EGF, epidermal growth factor; BMP2, bone morphogenetic protein 2; S100A8, calprotectin S100A8; Runx2/Cbfa1, core binding factor α1. * P < 0.05, indicate significant differences in the incidence of root abnormality between groups (Logistic regression analysis).
VDR rs2228570
	CC	59	45 (76.27)
	CT+TT	115	79 (68.70)	0.93 (0.56, 1.52)
CTR rs2283002
	CC	49	43 (87.76)	3.71 (1.45, 9.50)*
	CT+TT	117	76 (64.96)
CTR rs2374634
	TT	144	105 (72.92)
	TC+CC	28	19 (67.86)	1.28 (0.53, 3.06)
MMP-8 rs11225395
	AA	17	12 (70.59)
	GG+AG	161	115 (71.42)	1.04 (0.35, 3.12)
RANK rs11664594
	TT	59	46 (77.93)
	AT+AA	113	75 (66.37)	1.79 (0.87, 3.72)
DBP rs17467825
	GG	22	16 (72.37)
	AA+AG	150	107 (71.33)	0.93 (0.34, 2.54)
DBP rs4588
	AA	21	15 (71.43)
	CA+CC	155	79 (72.26)	1.04 (0.38, 2.86)
DBP rs7041
	TT	97	73 (7526)
	GT+GG	78	54 (69.23)	1.35 (0.69, 2.63)
EGF rs2237051
	AA	73	48 (65.75)
	GA+GG	102	79 (77.45)	0.56 (0.29, 1.09)
BMP2 rs2273073
	TT	156	114 (73.08)
	GT	17	12 (70.59)	1.13 (0.38, 3.40)
S100A8 rs3795391
	TT	136	96 (70.59)
	TC	40	30 (75.00)	0.80 (0.36, 1.79)
S100A8 rs3806232
	TT	130	89 (68.46)
	CT	48	38 (79.17)	0.57 (0.26, 1.26)
Runx2/Cbfa1 rs6938177	CC	87	60 (68.97)
	TC+TT	88	79 (73.86)	0.79 (0.41, 1.52)