Table 2.
Clinical and histopathological analysis among PTHR+ and PTHR− groups
| Peritumoral hypointense rim | Positive | Negative | P value |
|---|---|---|---|
| Sex (M/F) | 18/5 | 10/6 | 0.143 |
| Mean age (years) | 68.4 ± 7.34 | 70.7 ± 5.93 | 0.208 |
| Mean size (mm) | 26.7 ± 8.39 | 20.5 ± 6.91 | 0.005* |
| Etiology, HCV/HBV/NBNC | 8/4/11a | 14/1/1b | 0.001* |
| Background liver fibrosis (F0/1/2/3/4) | 1/4/7/5/6 | 0/1/2/5/8 | 0.042* |
| Differentiation (well/moderately/poorly differentiated) | 6/16/1 | 5/9/2 | 0.455 |
F, degree of fibrosis using the new Inuyama classification (F0, no fibrosis; F1, portal fibrosis widening; F2, portal fibrosis widening with bridging fibrosis; F3, bridging fibrosis and lobular distortion; and F4, cirrhosis); HBV hepatitis B virus, HCV hepatitis C virus, NBNC (non-B, non-C). *Statistical significance
aHCCs with a PTHR were identified in 7 patients with alcoholic liver disease, 3 patients with nonalcoholic steatohepatitis, and one patient with an unknown etiology
bHCC without a PTHR was identified in one patient with alcoholic liver disease