Fig. 1.

EBV-induced oncogenesis through the NF-κB signaling pathway. LMP1 can enhance the activity of NF-κB, enter the nucleus to activate transcription and promote cell proliferation, migration and invasion. LMP1 can inhibit the expression of miRNA-203 through NF-κB, resulting in high expression of CDH6 and EMT. At the same time, LMP1 can also activate the IKK2/TPL2/JNK signaling axis, which is beneficial to the survival of LCL. The combination of LMP1 and p65 can activate hTERT and inhibit PINX1, which together promote cell immortalization. EBV-miRNA-BART13 inhibits NKIRAS2, thereby promoting cell proliferation, migration and invasion