Table 1.

Population, intervention, comparison and outcomes (PICO) of the proposed question:

	Interventions to treat HCC patients with microvascular invasion
Population	HCC patients diagnosed with MVI by pathology after curative resection and Child class A or B without macrovascular invasion and metastatic disease
Intervention vs Comparison	TACE versus conservation therapy; pa-TACE versus re-resection/ radiofrequency ablation ablation; pa-TACE versus radiotherapy; sorafenib versus conservation therapy
Outcomes	OS and/or RFS
Study design	Retrospective study (PSM or not) and randomized clinical trial

Pa-TACE postoperative adjuvant transarterial chemoembolization