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Ameloblasts differentiate from primordial cells, first into a secretory epithelium type, then to a differentiated epithelium type, and finally to a reduced enamel epithelium type (from left to right). We postulate that the vectorial transfer of citrate from blood-side to the enamal side occurs in differentiated ameloblasts. ANKH, humna ankylosis gene product. The figure was adapted and modified from ref. [120].
