. Author manuscript; available in PMC: 2021 May 4.

Published in final edited form as: Leukemia. 2020 Nov 4;35(2):360–376. doi: 10.1038/s41375-020-01066-4

Table 4.

RBPs involved in mRNA polyadenylation

Gene	Protein/RNP function	Target Genes	Biological consequences	Type of cancer	Expression in cancer	Ref
*U1 snRNP*	telescripting - inhibits premature cleavage and polyadenylation	global transcription elongation	3’ UTR shortening, truncated mRNA, increased migration and invasion	HeLa	loss or change-of-function	⁵⁹ reviewed in⁵⁷
*PAP*	Poly(A) Polymerase	n/a (PAP activity in cell extracts)	PAP activity is higher in acute leukemia than in chronic leukemia	AML, ALL, CML	upregulation	reviewed in⁵⁴
*APA (process)*	alternative polyadenylation	NF-kB, GATA2, IAP-family of genes	global RNA shortening or lengthening	BM AML	upregulation	⁵⁶
*CPSF1*	cleavage and polyadenylation, recruits nuclear export	AML1-ETO	oncogenic mRNA stability	AML	upregulation	⁵⁵
*HuR*	AU-rich RNA binding protein, mRNA stability	elF4E, cEBPβ, p21, FOXO3, MEK1, MEK2, DUSP10, ZFP36L1, MYC	mRNA stability	AML, BC CML	upregulation	reviewed in⁶⁰
*TTP*	mRNAs degradation via the exosome or via Xrn1 exonuclease	VEGF, cytokines, c-IAP-2	proapoptotic function in cancers	BC CML, DLBCL, acute phase ATL	loss-of-function, tumor suppressor	reviewed in ⁶⁰

Abbreviations used: Acute myeloid leukemia (AML); acute promyeloblastic leukemia (APL); acute megakaryoblastic leukemia (AMKL); acute lymphoblastic or lymphocytic (ALL); B-cell acute lymphoblastic leukemia (B-ALL); adult T-cell leukemia/lymphoma (ATL); diffuse large B-cell lymphomas (DLBCLs); chronic myeloid leukemia (CML), chronic phase (CP), accelerated phase (AP), blast crisis (BC); chronic lymphoblastic or lymphocytic leukemia (CLL); myelodysplastic syndromes (MDS); multiple myeloma (MM); hepatocellular carcinoma (HCC); leukemia stem cell (LSC); wild type (WT); patient-derived xenograft (PDX); bone marrow (BM); hematopoietic stem/progenitor cells (HSCs, HSPCs).