. Author manuscript; available in PMC: 2021 May 4.

Published in final edited form as: Leukemia. 2020 Nov 4;35(2):360–376. doi: 10.1038/s41375-020-01066-4

Table 5.

RBPs involved in nuclear transport and translation.

Gene	Protein/RNP function	Target Genes	Biological consequences	Type of cancer	Expression in cancer	Ref
*XPO1/CRM1*	Exportin 1, ubiquitous nuclear export	protein export p53, NPM1, NFκB	anti-apoptotic properties	AML, ALL, CML, CLL, lymphoma, MM	upregulation	reviewed in⁶⁷
*eIF4E*	cap-dependent mRNA nuclear export and translation	CCND1	delays granulocytic and monocytic differentiation, promotes leukemogenesis	AML, BC CML, ALL	upregulation	⁷⁰
*eIF4E*	cap-dependent mRNA nuclear export and translation	MYC, BCL2, BCL6, B-cell receptor signaling, metabolism, and epigenetic regulation	promotes proliferation, aggressiveness	aggressive double- and triple-hit (DH/TH) DLBCL with active Hsp90 stress pathway	upregulation	⁷¹

Abbreviations used: Acute myeloid leukemia (AML); acute promyeloblastic leukemia (APL); acute megakaryoblastic leukemia (AMKL); acute lymphoblastic or lymphocytic (ALL); B-cell acute lymphoblastic leukemia (B-ALL); adult T-cell leukemia/lymphoma (ATL); diffuse large B-cell lymphomas (DLBCLs); chronic myeloid leukemia (CML), chronic phase (CP), accelerated phase (AP), blast crisis (BC); chronic lymphoblastic or lymphocytic leukemia (CLL); myelodysplastic syndromes (MDS); multiple myeloma (MM); hepatocellular carcinoma (HCC); leukemia stem cell (LSC); wild type (WT); patient-derived xenograft (PDX); bone marrow (BM); hematopoietic stem/progenitor cells (HSCs, HSPCs).