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. 2021 Feb 3;17:297–304. doi: 10.2147/NDT.S278422

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© 2021 Zhong et al.

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Western blot analysis of mTOR and p-mTOR expression in the hippocampus. (A) Western blot analysis; (B) expression of mTOR; (C) expression of p-mTOR. **P<0.01 compared with the sham ECS group. ▲P<0.05, ▲▲P<0.01, compared with the ECS group. ▽P<0.05 compared with the (2R,6R)-HNK+ECS group. ΔΔP<0.01 compared with the 3-MA+(2R,6R)-HNK+ECS group. Data were analyzed using one-way analysis of variance, with the Bonferroni post hoc test. Bars represent the means ± SEMs; n=3 per group.

Abbreviations: ECS, electroconvulsive shock; (2R,6R)-HNK, (2R,6R)-hydroxynorketamine; 3-MA, 3-methyladenine; SMER28, small-molecule enhancer of rapamycin 28; mTOR, mammalian target of rapamycin.