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. 2021 Jan 25;11:608294. doi: 10.3389/fimmu.2020.608294

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Copyright © 2021 Tatomir, Beltrand, Nguyen, Boodhoo, Mekala, Cudrici, Badea, Muresanu, Rus and Rus

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RGC-32 regulates the expression of CTGF in vitro. WT and RGC-32 KO mouse astrocytes were treated with 10 ng/ml TGF-β for the indicated periods of time and then examined for the expression of CTGF mRNA and protein by Real-Time PCR and Western blotting, respectively. CTGF mRNA expression was significantly higher at 24 h of stimulation in WT astrocytes (A), and CTGF protein levels were higher at 24 h and 48 h of stimulation in WT astrocytes than in RGC-32 KO astrocytes (B, C). The expression of the mRNA at the beginning of the experiment (CTR) was considered to be 100, and the results are shown as -fold change (A). The protein level is expressed as a ratio to β-tubulin (B), and a representative blot is shown in (C) Data are expressed as mean ± SEM (n=3). * = p<0.05; ** = p<0.01; *** = P<0.001.