TABLE 2.

Natural extracts with effects on depression associated with diabetes.

Medicinal plant	Active parts	Action	References
Allium sativum L.	Homogenate	1) Attenuates brain MDA levels and increases SOD and GPx activities.	Rahmani et al. (2020)
Aloe vera	Mucilaginous	1) Increases activities of hippocampal SOD and CAT and reduces MDA levels in the hippocampus tissue of STZ-induced diabetic rats	Tabatabaei et al. (2017)
Brassica juncea L.	Leave	1) Increases dopamine, norepinephrine, and serotonin in the brain.	Thakur et al. (2014)
Morus alba L.	Root bark	1) Restores BDNF levels in the prefrontal cortex through ERK and Akt signaling.	Ye et al. (2017)
Pueraria lobata (Willd.) Ohwi and Crataegus pinnatifida Bunge	Whole	1) Promotes BDNF expression and ERK activation to prevent depression in a diabetic rat model.	Luo et al. (2016)
Rosa canina L.	Fruits	1) Attenuates impairment of recognition memory and depressive-like behavior through the modulation of oxidative stress in the STZ model of diabetes in the mouse brain.	Farajpour et al. (2017)
Urtica dioica L.	Leaves	1) Improves hippocampal GLUT4 mRNA expression.	Patel and Udayabanu (2014); Patel et al. (2018)
		2) Upregulates BDNF, TrKB, Cyclin D1, Bcl2, and autophagy, downregulates iNOS mRNA expression in the hippocampus of diabetic mice, and decreases the expression of TNF-α in hippocampus of diabetic mice.