TABLE 2.
Medicinal plant | Active parts | Action | References |
---|---|---|---|
Allium sativum L. | Homogenate | 1) Attenuates brain MDA levels and increases SOD and GPx activities. | Rahmani et al. (2020) |
Aloe vera | Mucilaginous | 1) Increases activities of hippocampal SOD and CAT and reduces MDA levels in the hippocampus tissue of STZ-induced diabetic rats | Tabatabaei et al. (2017) |
Brassica juncea L. | Leave | 1) Increases dopamine, norepinephrine, and serotonin in the brain. | Thakur et al. (2014) |
Morus alba L. | Root bark | 1) Restores BDNF levels in the prefrontal cortex through ERK and Akt signaling. | Ye et al. (2017) |
Pueraria lobata (Willd.) Ohwi and Crataegus pinnatifida Bunge | Whole | 1) Promotes BDNF expression and ERK activation to prevent depression in a diabetic rat model. | Luo et al. (2016) |
Rosa canina L. | Fruits | 1) Attenuates impairment of recognition memory and depressive-like behavior through the modulation of oxidative stress in the STZ model of diabetes in the mouse brain. | Farajpour et al. (2017) |
Urtica dioica L. | Leaves | 1) Improves hippocampal GLUT4 mRNA expression. | Patel and Udayabanu (2014); Patel et al. (2018) |
2) Upregulates BDNF, TrKB, Cyclin D1, Bcl2, and autophagy, downregulates iNOS mRNA expression in the hippocampus of diabetic mice, and decreases the expression of TNF-α in hippocampus of diabetic mice. |