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. 2021 Jan 25;11:588259. doi: 10.3389/fphar.2020.588259

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Copyright © 2021 Zhang, Li, Ma, Liu, Wang, Zhang, Li, Li and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of Piezo1 using siRNA abrogates the protective effects of RRP on HUVEC injury. (A) The mRNA expression of Piezo1 detected by qRT-PCR in indicated groups. (B) Proliferation activity of HUVECs, *p < 0.05 vs. Piezo1 siRNA group. (C) Cellular alignment was analyzed by staining cells with phalloidin (red) and DAPI (blue), scale bars = 50 μm, arrows indicate the fluid direction. (D,F) Representative images of the migration of HUVECs and the calculated cell migration number, scale bars = 50 μm, *p < 0.05, **p < 0.001 vs. Piezo1 siRNA group, ^## p < 0.001 vs. Piezo1 siRNA + L-FSS group. (E) Representative images of the formation of capillary-like tubules in HUVECs, scale bars = 200 μm. (G,H) Capillary morphogenesis was quantified by calculating the branch points (G) and capillary length (H), **p < 0.001 vs. Piezo1 siRNA group, ^# p < 0.05, ^## p < 0.001 vs. Piezo1 siRNA + L-FSS group.