Table 2.
Comparison of features between MobiDetails and similar software.
| MobiDetails | VarSome | VEP web | MARRVEL | |
|---|---|---|---|---|
| Access and technical aspects | ||||
| Free usage for academics | y | y—limited | y | y |
| Free API usage for academics | y | n | y | y |
| Local installation | y* | n | y | n |
| User friendly | y | y | n—but extensive options | y |
| Encrypted connection by default (https) | y | y | n | n |
| Responsive website | y | y—limited | n | y |
| Specific content for interpretation | ||||
| Custom annotations | y—registered users | y—registered users | y—only on local instances | n |
| Selectable wild-type and mutant DNA sequence surrounding variants | y | n | n | n |
| gnomADv3: whole genome population variant frequencies | y | y | n | n |
| Extensive splice site predictions | y | n | y | n |
| miRNA target sites predictions | y | n | n | n |
| Literature search | y—LitVar | y—MasterMind | y | n |
| LOVD occurences | y | n | n | n |
| Pdf export | y | n | n | n |
| hg38 coordinates | y | y | y | n |
| All small variants type** | y | y | y | n—only substitutions |
*Requires the SQL scheme available upon request.
**Substitutions and small insertions/deletions.