Fig. 1. Distribution of recurrent ALPL variants according to the geographic origin of patients.

Variants are shown according to their frequency and their genetic status in ten regions defined to represent 32 countries: France/Switzerland, Germany/Austria, UK/Ireland, Belgium/Netherlands, North Europe (Denmark, Finland, Sweden, Norway, Lithuania), East Europe (Hungary, Croatia, Georgia, Poland, Czech republic), South Europe (Spain, Portugal, Greece, Italy), North America (USA/Canada), Australia/New Zeland and Middle East (Saudi Arabia, Israel, Japan, Jordan, Tunisia, Turkey). Moderate alleles are shown in green, severe alleles with no DNE in red and severe alleles with DNE in purple. Variants not classified are not shown.