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. 2021 Jan 25;11:626013. doi: 10.3389/fneur.2020.626013

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Copyright © 2021 Xiao, Yang, Yan, Feng, Long, Tu, Deng, Chen, Xiao, Long and Zeng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PPI network and module analysis. (A): Protein-protein interaction network of differentially expressed genes by the STRING database. We identified 144 PPI pairs among 119 differentially expressed genes. (B): Degree distribution histogram of hub genes. (C): A significant module selected from the entire PPI network using the Cytoscape MCODE app with the default parameters (Degree cutoff ≥2, Node score cut-off ≥0.2, K-Core ≥2 and Max Depth = 100). Red nodes represent upregulated proteins and blue nodes represent downregulated proteins.