Table 2.
Top 10 upregulated and downregulated proteins in MTLE patients compared to controls by iTRAQ.
| Gene | Protein name | Fold-change | P-value | Changes |
|---|---|---|---|---|
| FCHO2 | F-BAR domain only protein 2 isoform X7 | 256.14 | 2.16E-13 | UP |
| STXBP1 | Syntaxin-binding protein 1 isoform b | 177.09 | 3.08E-08 | UP |
| TATDN1 | Putative deoxyribonuclease TATDN1 isoform d | 160.63 | 4.23E-12 | UP |
| MPZL1 | Myelin protein zero-like protein 1 isoform b precursor | 131.58 | 1.53E-15 | UP |
| NDUFA5 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform 1 | 122.48 | 1.08E-12 | UP |
| SVOP | Synaptic vesicle 2-related protein | 93.36 | 4.27E-12 | UP |
| ATP5ME | ATP synthase subunit e, mitochondrial | 88.21 | 2.01E-09 | UP |
| NUP50 | Nuclear pore complex protein Nup50 isoform a | 87.22 | 8.44E-12 | UP |
| MAP4K2 | Mitogen-activated protein kinase kinase kinase kinase 2 isoform X7 | 80.07 | 5.16E-11 | UP |
| RIN1 | Ras and Rab interactor 1 isoform 3 | 78.40 | 4.75E-08 | UP |
| RBBP4 | Histone-binding protein RBBP4 isoform a | 0.003 | 1.83E-13 | DOWN |
| UQCR10 | Cytochrome b-c1 complex subunit 9 isoform a | 0.004 | 1.1E-08 | DOWN |
| EGLN1 | Egl nine homolog 1 | 0.008 | 1.52E-11 | DOWN |
| GSTT2 | Glutathione S-transferase theta-2 isoform b | 0.008 | 1.92E-09 | DOWN |
| SNAPIN | SNARE-associated protein Snapin | 0.009 | 3.27E-12 | DOWN |
| NDUFS5 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 | 0.009 | 6.33E-08 | DOWN |
| LRRTM1 | Leucine-rich repeat transmembrane neuronal protein 1 precursor | 0.010 | 1.05E-06 | DOWN |
| RPS17 | 40S ribosomal protein S17 | 0.011 | 6.58E-08 | DOWN |
| MTFR1L | Mitochondrial fission regulator 1-like isoform a | 0.011 | 1.38E-08 | DOWN |
| ABCF2 | ATP-binding cassette sub-family F member 2 isoform a | 0.013 | 3.05E-11 | DOWN |