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. 2021 Jan 25;7:610229. doi: 10.3389/fmolb.2020.610229

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Copyright © 2021 Xu, Hu, Anwaier, Wang, Liu, Tian, Zhu, Ma, Wan, Shi, Qu, Zhang and Ye.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential FASN mRNA expression and its correlation with advanced clinicopathological parameters in ccRCC patients from TCGA cohort. (A) To explore the potential relationship between FASN expression and clinicopathological features of ccRCC patients, we enrolled 533 ccRCC samples and 72 adjacent normal samples from TCGA cohort and found significantly increased FASN mRNA expression in ccRCC compared with normal samples (p < 0.05). (B) The FASN mRNA expression was found to be markedly related with advanced clinical AJCC stage (p < 0.05) and reached the highest in advanced stage 4 (C,D) Survival analysis in the Kaplan–Meier method indicated that elevated FASN expression was significantly associated with shorter PFS (p = 0.011) and OS (p < 0.001) in TCGA cohort.