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. 2021 Jan 25;7:610229. doi: 10.3389/fmolb.2020.610229

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Copyright © 2021 Xu, Hu, Anwaier, Wang, Liu, Tian, Zhu, Ma, Wan, Shi, Qu, Zhang and Ye.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional annotations and predicted signaling pathways in silico. (A) A PPI network of FASN and its co-expression genes was established, including ACACA, ACACB, ACLY, AASDHPPT, ACSL1, ACSL3, CDC5L, MCAT, OLAH, and SREBF1. (B) Functional enrichment analyses of a total of 11 involved genes were performed and visualized in a bubble chart. Significant genes involved in fatty acid biosynthetic process, fatty acid metabolic process, carboxylic acid, organic acid, and lipid biosynthetic process markedly participated in carboxylic acid binding and vitamin binding. (C) Horizontal and vertical cluster analyses were performed in 533 ccRCC samples from TCGA database and 11 related genes, and the heat map was obtained after standardization. (D) Functional annotation using ClueGO indicated that changes in the biological processes of the FASN were significantly associated with fatty acid biosynthesis, fatty acid biosynthetic process, and fatty acid synthase activity.