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. 2021 Jan 25;7:610229. doi: 10.3389/fmolb.2020.610229

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Copyright © 2021 Xu, Hu, Anwaier, Wang, Liu, Tian, Zhu, Ma, Wan, Shi, Qu, Zhang and Ye.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Significant related genes and hallmarks pathways in ccRCC predicted by GSEA. (A–F) The most significant pathways include E2F targets, down-regulation of Kras signaling, estrogen response, and G2M checkpoint. (G) Transcriptional expression profiles of a total of 100 significant genes with positive and negative correlation were performed in a heat map.