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. 2021 Jan 25;11:608377. doi: 10.3389/fimmu.2020.608377

Figure 3.

Figure 3

Experimental Autoimmune Uveoretinitis (EAU): a model for sight-threatening posterior uveitis. Clinical and histological signs of EAU in mice. EAU may be induced by subcutaneous injection of interphotoreceptor retinol binding protein (IRBP) peptide 161–180 in B10.RIII mice or peptide 1–20 in C57BL/6 mice with Complete Freund’s Adjuvant (CFA) and pertussis toxin (Ptx). Disease is mediated by a Th1/IL12 and/or a Th17/IL23 mechanism with dominant effect being Th17 mediated disease. The images are from the C57/BL6 mouse model. Clinical images are shown: (A) early focal chorioretinal infiltrate (arrowhead); (B) developing retinal vasculitis shown as focal perivascular “sheathing” (arrows); (C) extensive retinal vasculitis and large granulomatous infiltrate; (D) severe retinal inflammation, damage and atrophy; (E) Section of normal mouse retina; (F) EAU showing severe inflammation with large central area of retinal necrosis and loss of photoreceptors. Modified from (48) under copyright agreement with Elsevier Publishing license number 4887001207791.