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. 2021 Jan 25;12:606927. doi: 10.3389/fnagi.2020.606927

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Copyright © 2021 Jiang, Ma, Wang, Wang, Yang, Li and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Experimental protocol. The three groups (n = 90) were subjected to stereotaxic surgery: group 1: 6-OHDA-lesion group, group 2: 6-OHDA-lesion + sham group, and group 3: 6-OHDA-lesion + PNU-282987 (α7nAChR agonist) group. For the PNU-282987 treatment, rats received intraperitoneal injections of PNU-282987 at a concentration of 3 mg/kg 2 h prior to lesion induction with 6-OHDA and then at days 1, 7, and 13 postlesion. Rats in the 6-OHDA-lesion + sham group received intraperitoneal injections of the equivalent amount of saline at the same time points. The rats (n = 6 per group) were sacrificed on day 14 for TH staining after assessing the motor deficits. Then the other rats were also sacrificed for morphological (n = 12 per group), Western blot (n = 6 per group), and RT-PCR (n = 6 per group) analysis at 14 days postlesion.