Table 2.
Diverse functions of exosomal integrin.
| Diseases/process | Pathophysiologic role of exosomal integrin | Reference |
|---|---|---|
| Oncology | ||
| Tumor metastasis | Organotropic metastasis and tumor microenvironment formation | Hoshino et al., 2015 |
| Prostate cancer | Cell migration and induce integrin expression through uptake of exosomes | Fedele et al., 2015 |
| Prostate cancer | Macrophage polarization and transferring αvβ6 integrin from cancer cells to monocytes through exosomes | Lu et al., 2018 |
| Prostate cancer | Determined cargo loading of exosomes which promoted cancer cell formation | Quaglia et al., 2020 |
| Fibrosarcoma | Promoted cell migration | Sung et al., 2015 |
| Neurology | ||
| Demyelination | Oligodendrocyte precursor cells proliferation | Zhang et al., 2020 |
| CNS diseases | Therapeutic protein delivery, exosome uptake, and spread of viral proteins to the brain | Yuan et al., 2017 |
| Pulmonary | ||
| COPD | Mediated exosome adhesion to extracellular matrix | Genschmer et al., 2019 |
| Gut | ||
| lymphocyte homing | Exosomal integrin α4β7 target high endothelial venule (HEV) endothelial cells causing diminish in lymphocyte homing niche | Myint et al., 2020 |