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. 2019 Jul 11;116(5):956–969. doi: 10.1093/cvr/cvz187

Figure 1.

Figure 1

The expression level of Adamts16 is up-regulated and correlated with the levels of Mmp2, Mmp9, Col1a1, and Col3a1 in the hearts from TAC mice with pressure-overload-induced cardiac hypertrophy and heart failure. (A) Western blot analysis for ADAMTS16 using heart protein extracts from TAC mice and control sham mice. Tubulin was used as loading control. Data are shown as mean ± SD. **P < 0.01 (n = 6). (B) Quantification of Western blot images as in (A). (C) Real-time RT–PCR analysis for Adamts16 using total cardiac RNA samples from 16-week-old TAC mice and control sham mice. Data are shown as mean ± SD. **P < 0.01 (n = 6). (D) Real-time RT–PCR analysis showed that the expression levels of Adamts16 significantly correlated with the levels of Mmp2 (r = 0.84), Mmp9 (r = 0.78), Col1a1 (r = 0.75), and Col3a1 (r = 0.79) in TAC mice. P < 0.05 (n = 12). Statistical analysis was carried out by a Student’s t-test.