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. 2019 Aug 20;116(5):944–955. doi: 10.1093/cvr/cvz205

Figure 4.

Figure 4

HuR ablation aggravates ISO-induced cardiac remodelling. (A, B) HuR KO and wild-type mice (6–8 weeks old) were injected with ISO (7.5 mg/kg/day) for 2 weeks. Masson (A) and H & E (B) staining were performed to evaluate the cardiomyocyte fibrosis in heart and heart slices. (C) The percent of fibrosis area are shown as the means ± SD from six mice; significance is analysed by Student’s t-test (*P < 0.05). (D) WGA staining was performed to measure the size of cardiomyocytes in the heart slices. Data are means ± SD from three mice; significance is analysed by Mann–Whitney U test (*P < 0.05). (E) Statistical significance of heart weight and the ratio between heart and body weight from six mice were analysed by Student’s t-test (*P < 0.05). (F) Representative images of the Doppler imaging of echocardiography. (G) Echocardiography analysis to evaluate the diastolic left ventricular anterior wall (LVAW; d) and diastolic left ventricular posterior wall (LVPW; d) (left) as well as the ejection fraction (EF) and fractional shortening (FS) (right). Data are the means ± SD from six mice; significance is analysed by Student’s t-test (*P < 0.05).