Table 1.

Multiple functions exerted by m⁶A RNA methyltransferases in various cancers

Molecule	Role	Cancer	Target	Mechanism	References
METTL3	oncogene	lung cancer	mRNA	METTL3-eIF3 cycle promotes translation of oncogenes	18
	oncogene	AML	mRNA	enhances protein translation	19
	oncogene	breast cancer	mRNA	HBXIP-let-7g-METTL3-HBXIP positive feedback pathway	20
	oncogene	CRC, GC, HCC	mRNA	activates the glycolysis of tumor cells	21, 22, 23
	oncogene	HCC	mRNA	regulates sorafenib resistance by mediating autophagy	24
	oncogene	pancreatic cancer, HCC, CRC	miRNA	accelerates the maturation of oncogenic miRNA	25, 26, 27, 28
	oncogene	HCC	lncRNA	upregulates the expression of oncogenic LNC00958	29
	suppressor	endometrial cancer	mRNA	inhibits the activation of AKT signaling pathway	30
METTL14	oncogene	AML	mRNA	inhibits myeloid differentiation of AMLs	31
	oncogene	pancreatic cancer	mRNA	activates the signaling pathway	32
	suppressor	RCC	mRNA	inhibits the expression of the oncogene P2RX6	33
	oncogene	breast cancer	miRNA	promotes the maturation of oncogenic miRNA	34
	suppressor	HCC	miRNA	promotes the maturation of cancer suppressor miRNA	35
	suppressor	CRC	lncRNA	downregulates the expression of carcinogenic lncRNA XIST	36
WTAP	oncogene	GC	–	involved in the immune regulation of tumor cells	37
	oncogene	DLBCL	–	stabilizes expression of transcriptional repressor BCL6	38
	oncogene	AML	–	inhibits myeloid differentiation of AMLs	39
VIRMA	oncogene	HCC	mRNA	inhibits the expression of tumor suppressor gene GATA3	40
	oncogene	PCa	lncRNA	upregulates the expression of oncogenic lncRNA CCAT1 and CCAT2	41
	oncogene	breast cancer	mRNA	regulates the expression of CDK1 and regulates the tumor cell cycle	42
HAKAI	oncogene	NSCLC	–	promotes EMT and mediates gefitinib resistance	43
	oncogene	tumor cell line	mRNA	interacts with PSF to stabilize oncogene expression	44,45
ZC3H13	oncogene	CRC	–	MLL1-ZC3H13 gene fusion, affecting mitosis	46
	suppressor	CRC	mRNA	inhibits activation of the Ras signaling pathway	47
RBM15	oncogene	AMKL	–	RBM15-MKL1 gene fusion	48
	oncogene	breast cancer	–	RBM15 gene mutation	49
METTL16	oncogene	CRC	–	METTL16 gene frameshift mutation	50

CRC, colorectal carcinoma; GC, gastric cancer; HCC, hepatocellular carcinoma; RCC, renal cell carcinoma; DLBCL, diffuse large B cell lymphoma; AML, acute myeloid leukemia; PCa, prostate carcinoma; NSCLC, non-small cell lung cancer; AMKL, acute megakaryocytic leukemia.