Table 2. Histopathologic findings of liver biopsies in immunocompetent patients.

Study	Liver biopsy findings
Bonkowsky et al.43	Portal triads infiltrated with lymphocytes, histiocytes, plasma cells, and neutrophils. Lobules with lymphocytes, monocytes and proliferating reticuloendothelial cells. Granulomata in the lobules. One large epithelioid granuloma with areas of necrosis.
	Normal lobular architecture. Many of the portal triads were enlarged, containing a small to moderate number of lymphocytes and histiocytes. Proliferation of RE cells and infiltration of lymphocytes in the sinusoids. Few necrotic hepatocytes. Small, sharply circumscribed granulomata made of closely packed epithelioid cells and rare lymphocytes. No giant cells.
Chan et al.47	Mild to moderate infiltrate of small lymphocytes in the sinusoids and a beaded sinusoidal infiltrate characteristic of HCMV infection.
Clarke et al.52	Focal areas of necrosis and many noncaseating epithelioid granulomas and portal triaditis.
	Non-caseating epithelioid granulomas, focal liver cell necrosis, portal triaditis.
	Prominent sinusoidal lymphocytic infiltrate and early granuloma formation.
Groza et al.53	Viral hepatitis in an advanced phase.
Miguelez et al.42	Intense mononuclear portal infiltration and severe alteration of zone 3 with confluent necrosis.
Reller et al.41	Non-specific resolving hepatitis with sparce cellular necrosis and mononuclear infiltrates in portal areas. Scattered granulomas with giant cell formation.
Sacks et al.40	Acute hepatitis with focal parenchymal necrosis, periportal and sinusoidal mononuclear infiltration. Focal fatty degenerative changes.
Serna-Higuera et al.61	HCMV intranuclear inclusions. Portal spaces with fibrous expansion and irregularly distributed lymphocytic infiltrate. Fibrin ring granulomas.
Shusterman et al.45	Hepatic lobules markedly disrupted by broad bands of necrosis.
Ten Napel et al.44	Enlargement of portal tracts, lymphocytic infiltrate, bile duct inflammation, focal necrosis, granulomas.
	Enlargement of portal tracts, lymphocytic infiltrate, lymphocytic spill-over, granulomas, liver cell degeneration.
	Enlargement of portal tracts, lymphocytic infiltrate, liver cell degeneration.
	Enlargement of portal tracts, lymphocytic infiltrate, bile duct inflammation, lymphocytic spill-over, liver cell degeneration.
	Enlargement of portal tracts, lymphocytic infiltrate, granulomas, focal necrosis.
Toghill et al.58	Areas of liver cell necrosis and mononuclear cell infiltration, acidophil bodies, slight portal enlargement, siderosis.
	Portal and periportal infiltration with chronic inflammatory cells, piecemeal necrosis, fibrosis of portal areas extending to lobules.