Table 3. Summary of the main histological findings of liver biopsies in immunocompetent and immunocompromised patients.

	Immunocompetent	Immunocompromised
Portal tracts	Enlarged portal tracts Prominent mononuclear portal and peri-portal infiltrate (frequent) Reported inflammatory cells: lymphocytes, histiocytes, plasma cells, neutrophils Fibrosis of portal areas (rare)	Mild to low mononuclear portal infiltrate Reported inflammatory cells: mainly lymphocytes
Parenchyma	Giant cell granulomas (frequent) Lymphocytes, monocytes Sinusoidal lymphocytic infiltrate (frequent) Few necrotic hepatocytes Focal areas of necrosis (rare)	Micro-abscesses (frequent) Giant cell granulomas (very rare) Parenchymal and sinusoidal inflammatory reaction Extensive focal liver necrosis
Presence of viral inclusion bodies	Extremely rare	Moderate (in inflammatory cells of portal mononuclear infiltrate and in hepatocytes)