Fig. 1. Treatments for metabolic dysfunction-associated fatty liver disease (MAFLD) and metabolic dysfunction-associated steatohepatitis (MASH) according to mechanism of action.

Abbreviations: ARB, angiotensin receptor blocker; CCR2/5, C-C motif chemokine receptor; ER, endoplasmic reticulum; FFA, free fatty acids; FXR, farnesoid X receptor; GLP, glucagon-like peptide; HSC, hepatic stellate cell; LOXL 2, lysyl oxidase-like homolog 2; PPAR, peroxisome proliferator-activated receptor; SHP, small heterodimer partner; SREBP, sterol regulatory element binding protein; TG, triglycerides; TGR5, Takeda G protein-coupled receptor 5; THR, thyroid hormone receptor; TNF, tumor necrosis factor; UDCA, ursodeoxycholic acid; VLDL, very low-density lipoprotein.