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. 2021 Feb 1;11(2):530–545.

Figure 2.

Figure 2

Effects of BRD4 targeting drugs on expression of MYC mRNA in solid tumor cells. Cancer cell lines were incubated in control medium (co) or in medium containing various concentrations of JQ1, dBET1 or dBET6 (0.005-5 µM) at 37°C for 16 hours. Expression of MYC mRNA was determined by qPCR analysis. The relative expression levels of MYC mRNA were calculated by the standard curve method and Actin was used as internal control. The figures show the mean ± SD of 3 independent experiments. Statistical analysis was performed by using ANOVA and post hoc Scheffe test. Asterisk (*): P < 0.05 compared to respective concentration of dBET6 (JQ1 vs. dBET6 and dBET1 vs. dBET6).