Figure 3.

Effects of BRD4 targeting drugs on proliferation of solid tumor cells. Cancer cell lines were incubated in control medium (co) or in medium containing various concentrations of JQ1, dBET1 or dBET6 (0.001-5 µM) at 37°C for 48 hours. Thereafter, ³H-thymidine uptake was measured. Results are expressed as percent of control (co) and represent the mean ± SD of 3 independent experiments. Statistical analysis was performed by using ANOVA and post hoc Scheffe test. Asterisk (*): P < 0.05 compared to respective concentration of dBET6 (light-grey asterisk: JQ1 vs. dBET6; dark-grey asterisk: dBET1 vs. dBET6).