Table 2.

Pearson correlation between BET drug-induced apoptosis and BRD4 and MYC baseline expression in solid tumor cells

	BRD4		MYC
	r	P	r	P
JQ1	0.81	0.0001	0.76	0.0005
dBET1	0.70	0.002	0.93	< 0.0001
dBET6	0.50	0.04	0.42	0.1

Cell lines were cultured in control medium or in medium containing 10 µM of JQ1, dBET1 or dBET6 at 37°C for 48 hours. Thereafter, cells were labeled with Annexin-V-FITC and examined by flow cytometry to determine the percentage of apoptotic cells. Baseline expression of BRD4 and MYC mRNA was determined by qPCR analysis in cells grown in control medium in the absence of drugs.