Table 2.
Univariate and multivariate analyses of overall survival in breast cancer patients
| Variables | Category | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|---|
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|
|
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| HR | 95% CI | P-value | HR | 95% CI | P-value | ||
| Age (Years) | > 35 vs. ≤ 35 | 0.631 | 0.388-1.027 | 0.063 | 1.080 | 0.245-4.749 | 0.918 |
| Tumor size | T2, T3 vs. T1 | 1.055 | 0.732-1.520 | 0.770 | |||
| Histological grade | Grade 3 vs. grade 1, 2 | 1.826 | 1.068-3.111 | 0.027 | 1.015 | 0.676-1.524 | 0.947 |
| ER | Negative vs. positive | 1.765 | 1.028-4.536 | 0.041 | 2.472 | 1.126-4.614 | 0.020 |
| PR | Negative vs. positive | 0.405 | 0.629-2.541 | 0.329 | |||
| HER2 | Positive vs. negative | 1.280 | 0.854-1.919 | 0.230 | |||
| Lymph node metastasis | Positive vs. negative | 8.157 | 3.542-17.034 | < 0.001 | 5.873 | 2.906-11.840 | < 0.001 |
| TNM stage | III vs. I + II | 3.392 | 1.677-6.880 | 0.001 | 3.325 | 1.336-8.250 | 0.011 |
| Ki-67 status | > 20% vs. ≤ 20% | 1.193 | 0.990-1.438 | 0.062 | 1.110 | 0.643-1.913 | 0.705 |
| P53 status | Positive vs. negative | 0.742 | 0.437-1.258 | 0.268 | |||
| YEATS4 | Positive vs. negative | 2.270 | 1.397-3.691 | 0.001 | 1.969 | 1.146-3.382 | 0.013 |
ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor 2; TNM, tumor-node-metastasis; YEATS4, YEATS domain-containing protein 4. P-values that reach significance are in bold.