Table 3.
Univariate and multivariate analyses of distant metastasis-free survival in breast cancer patients
| Variables | Category | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|---|
|
|
|
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| HR | 95% CI | P-value | HR | 95% CI | P-value | ||
| Age (Years) | > 35 vs. ≤ 35 | 0.972 | 0.389-2.434 | 0.952 | |||
| Tumor size | T2, T3 vs. T1 | 1.954 | 0.936-4.083 | 0.075 | 1.005 | 0.634-1.960 | 0.725 |
| Histological grade | Grade 3 vs. grade 1, 2 | 1.270 | 0.518-3.132 | 0.607 | |||
| ER | Negative vs. positive | 1.775 | 1.079-2.941 | 0.025 | 1.443 | 0.862-2.387 | 0.166 |
| PR | Negative vs. positive | 1.806 | 1.194-3.007 | 0.007 | 1.107 | 0.589-1.752 | 0.640 |
| HER2 | Positive vs. negative | 1.651 | 0.827-3.304 | 0.157 | |||
| Lymph node metastasis | Positive vs. negative | 4.017 | 2.209-7.303 | < 0.001 | 3.543 | 1.939-6.440 | < 0.001 |
| TNM stage | III vs. I + II | 2.521 | 1.146-5.541 | 0.021 | 2.244 | 1.018-4.944 | 0.450 |
| Ki-67 status | > 20% vs. ≤ 20% | 1.277 | 0.736-2.213 | 0.385 | |||
| P53 status | Positive vs. negative | 0.714 | 0.165-3.014 | 0.656 | |||
| YEATS4 | Positive vs. negative | 1.892 | 1.137-3.188 | 0.015 | 1.784 | 1.061-3.002 | 0.029 |
ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor 2; TNM, tumor-node-metastasis; YEATS4, YEATS domain-containing protein 4. P-values that reach significance are in bold.