MYBL2 promotes tumor aggressive progression dependent on CDCA8. (A-C) PCMV or CDCA8 plasmids were introduced to HEY cells that transfected with PLKO.NC or shMYBL2. Cell proliferation was detected by MTT assays (A) and colony formation assays (B). Migration and invasion abilities were determined by transwell assays (C) (200 ×), Scale bar: 100 µm. (D-F) MYBL2 over-expressing SKOV3 cells were transfected with siCDCA8 or NC. MTT assays (D), colony formation assays (E) and transwell assays (F) were performed to analyze the effect of CDCA8 depletion on SKOV3 cells stably transfected with MYBL2 (200 ×), Scale bar: 100 µm. (Data are mean ± SEM, *P < 0.05, **P < 0.01, n = 3).