Table 1.
The differential metabolites in HSYA treated CCI rats.
| Metabolites | Formula | Molecular Weight | RT (min) | MS/MS | Adduct | KEGG ID | Part | CCI vs. sham 1d |
HSYA vs. CCI 1d |
CCI vs. sham 3d |
HSYA vs. CCI 3d |
||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| VIP | q-value | VIP | q-value | VIP | q-value | VIP | q-value | ||||||||
| L-Phenylalanine | C9H11NO2 | 165.078 | 5.991 | 53.040;77.039;119.073 | [M+H]+ | C00079 | Cortex | 5.181 | 0.000 | 4.321 | 0.005 | 6.829 | 0.000 | 6.070 | 0.000 |
| Choline | C5H13NO | 103.100 | 6.742 | 60.082;67.546;87.045 | [M+H]+ | C00114 | Cortex | 5.137 | 0.006 | 6.844 | 0.005 | 6.578 | 0.000 | 3.885 | 0.049 |
| Arachidonic acid | C20H32O2 | 304.241 | 0.929 | 97.066;205.195;303.233 | [M−H]- | C00219 | Cortex | 4.424 | 0.011 | 5.643 | 0.013 | 5.540 | 0.000 | 4.156 | 0.039 |
| L-Norleucine | C6H13NO2 | 131.094 | 6.840 | 56.050;69.071;86.097 | [M+H]+ | C01933 | Cortex | 4.286 | 0.000 | 3.516 | 0.000 | 4.917 | 0.000 | 4.150 | 0.000 |
| Oleic acid | C18H34O2 | 282.256 | 0.935 | 71.013;127.076;282.252 | [M−H]- | C00712 | Cortex | 4.024 | 0.000 | 4.630 | 0.000 | 4.481 | 0.000 | 4.158 | 0.000 |
| Cytidine | C9H13N3O5 | 243.085 | 4.208 | 266.075;134.033;91.752 | [M+H]+ | C00475 | Cortex | 3.717 | 0.000 | 2.094 | 0.040 | 3.878 | 0.000 | 2.554 | 0.025 |
| L-Proline | C5H9NO2 | 115.063 | 9.102 | 68.050;98.060;116.017 | [M+H]+ | C00148 | Cortex | 3.260 | 0.000 | 2.296 | 0.016 | 3.575 | 0.000 | 2.124 | 0.013 |
| L-Methionine | C5H11NO2S | 149.050 | 7.945 | 61.011;102.055;122.032 | [M+H]+ | C00073 | Cortex | 2.722 | 0.000 | 2.417 | 0.005 | 3.231 | 0.000 | 2.626 | 0.000 |
| 4-Oxoproline | C5H7NO3 | 129.041 | 7.498 | 82.028;84.044;127.896 | [M−H]- | C01877 | Cortex | 3.089 | 0.000 | 3.374 | 0.000 | 3.155 | 0.000 | 3.710 | 0.000 |
| L-Arginine | C6H14N4O2 | 174.111 | 21.974 | 70.066;116.071;175.119 | [M+H]+ | C00062 | Cortex | 3.516 | 0.000 | 2.700 | 0.010 | 3.076 | 0.000 | 1.919 | 0.08 |
| Xanthine | C5H4N4O2 | 152.032 | 2.984 | 65.997;108.019;151.025 | [M−H]- | C00385 | Cortex | 4.316 | 0.000 | 3.705 | 0.005 | 2.791 | 0.003 | 3.317 | 0.019 |
| γ-Aminobutyric acid | C4H9NO2 | 103.064 | 17.100 | 69.034;86.061;104.071 | [M+H]+ | C00334 | Cortex | 3.599 | 0.016 | 5.266 | 0.008 | 2.498 | 0.012 | 4.590 | 0.000 |
| Hypoxanthine | C5H4N4O | 136.038 | 2.295 | 82.041;104.108;106.065 | [M+H]+ | C00262 | Hippocampus | 10.170 | 0.000 | 12.954 | 0.000 | 7.231 | 0.000 | 11.798 | 0.000 |
| Choline | C5H13NO | 103.100 | 7.120 | 74.876;67.546;87.045 | [M+H]+ | C00114 | Hippocampus | 7.301 | 0.000 | 7.650 | 0.000 | 5.720 | 0.000 | 7.038 | 0.000 |
| Uridine | C9H12N2O6 | 244.069 | 2.273 | 82.028;140.034;200.056 | [M+Cl]- | C00299 | Hippocampus | 2.048 | 0.044 | 5.681 | 0.000 | 3.404 | 0.006 | 6.675 | 0.000 |
| L-Tryptophan | C11H12N2O2 | 204.089 | 6.620 | 74.023;116.049;203.082 | [M−H]- | C00078 | Hippocampus | 1.218 | 0.000 | 2.286 | 0.000 | 1.106 | 0.000 | 2.015 | 0.000 |