Table 1.
AGAP2-AS1 expression and regulation mechanism in vivo
| Cancer types | Animal model | Cell lines transfection | Interventions and groups | Regulation Mechanism | References |
|---|---|---|---|---|---|
| GBM | BALB/C male nude mice | U87/MG | sh-NC | Knockdown of AGAP2-AS1 triggers a reduction of AGAP2-AS1 expression, an increase of TFPI2 protein level in excised tumor masses Silencing of AGAP2-AS1 obviously slows down the tumor growth | [47] |
| sh-AGAP2-AS1 | |||||
| CRC | 24 male BALB/c nude mice | RKO, HT29 | RKO/pWPXL, RKO/AGAP2-AS1, HT29/pWPXL, and HT29/AGAP2-AS1 | AGAP2-AS1 promotes the growth of RKO and HT29 cells in nude mice | [23] |
| PC | BALB/C male nude mice | BxPC-3 | sh-NC | sh-AGAP2-AS1 downregulates tumor growth as well as reduces tumor volume and weight | [29] |
| sh-AGAP2-AS1 | |||||
| GC | BALB/c nude mice | BGC823 | sh-AGAP2-AS1 | sh-AGAP2-AS1 inhibits GC cell tumor growth in vivo | [18] |
| sh-NC | |||||
| EC | 24 male BALB/c nude mice | KYSE70 | sh-NC & oe-NC | si-AGAP2-AS1 inhibits tumor volume and weight | [24] |
| sh-AGAP2-AS1 & oe-NC, | Suppressed in vivo tumorigenesis through downregulating FOSL1 | ||||
| sh-AGAP2-AS1 & oe-FOSL1 | |||||
| HCC | 4-6 week-old female BALB/c nude mice | Hep3B, HCCLM3 | sh-AGAP2-AS1 | AGAP2-AS1 knockdown inhibits the tumor growth of HCC cells in mice | [67] |
| sh-NC | AGAP2-AS1 overexpression increases the Ki67 positive staining cells and reduces the number of apoptotic cells | ||||
| AGAP2-AS1 knockdown inhibits proliferation and induces apoptosis cells |