Table 2.
Expression and regulation mechanism of AGAP2-AS1 levels in cancers cell lines
| Cancer Type | Cell lines | Target miRNA | Target gene | Activity | Pathways | PMID |
|---|---|---|---|---|---|---|
| GBM | U87, U251 | Downregulation of AGAP2-AS1 inhibits proliferation, migration, and invasion, and promotes apoptosis | [46] | |||
| Glioma | U87, U251 LN229, normal human astrocyte | miR-15a/b-5p | HDGF | Know-down of AGAP2-AS1 decreases cell viability and proliferation, cell apoptosis, and cell growth | Wnt/β-catenin signaling pathway | [37] |
| GBM | U87/MG, U251/MG, A172 | EZH2, LSD1, TFPI2 | Knockdown of AGAP2-AS1 suppresses proliferation and invasion, and facilitated apoptosis | AGAP2-AS1/EZH2 and LSD1/TFPI2 patrhway | [47] | |
| Lung cancer | H1299, H1975 | EZH2, LSD1 | Overexpressed AGAP2-AS1 increases proliferation, migration, invasion, and tumorigenesis | EZH2 and LSD1/LATS2 and KLF2/H3K27 trimethylation or H3K4me2 demethylation | [49] | |
| Breast cancer | Trastuzumab-resistant SKBR-3 and BT474 cells | Myd88, HIF-1α | Increased AGAP2-AS1 facilitates tumor growth and trastuzumab resistance, and inhibits apoptosis | SP1/AGAP2-AS1/Myd88/NF-κB signaling pathway | [39] | |
| Breast cancer | SKBR-3 and BT474 cells | AGAP2-AS1 expression is increased in trastuzumab resistant cells | [22] | |||
| Exosome AGAP2-AS1 expression was upregulated by hnRNPA2B1 overexpression | ||||||
| Breast cancer | Increased lncRNA AGAP2-AS1 promotes trastuzumab resistance | [39] | ||||
| CRC | DLD-1, SW480 | miR-497 | FGFR1 | AGAP2-AS1 promotes proliferation, migration and invasion and inhibited apoptosis | [23] | |
| AGAP2-AS1 promotes G1/M phase cell cycle arrest and increased gemcitabine sensitivity | ||||||
| CRC | SW620, HT-29 and HCT8 | miR-4668-3p | SRSF1 | Upregulated AGAP2-AS1 promotes cell proliferation, migration and EMT process | RREB1/AGAP2-AS1/miR-4668-3p/SRSF1 | |
| PC | HPDE6-C7, AsPC-1, SW1990, PANC-1, BxPC-3 | EZH2 | AGAP2-AS1 promotes proliferation and apoptosis, migration and invasion | AGAP2-AS1/EZH2/ANKRD1 and ANGPTL4 axis | [29] | |
| GC | BGC823, AGS cells | EZH2, LSD1 | AGAP2-AS1 promotes proliferation, cell cycle arrest, cell migration, invasion, and tumorigenesis | SP1/AGAP2-AS1/EZH2 and LSD1/P21, E-cadherin | [18] | |
| EC | KYSE70, KYSE-510, and EC9706) and human immortalized esophageal epithelial cells | miR-195-5p | FOSL1 | AGAP2-AS1 promotes proliferation, invasion, and migration as well as tumor growth | AGAP2-AS1/miR-195-5p/FOSL1 | [24] |
| Regulated cell cycle, and apoptosis | ||||||
| HCC | LO2, Hep3B, HCCLM3, Huh7, MHCC-97H, SMMC-7721 | miR-16-5p | ANXA11, AKT | AGAP2-AS1 promotes proliferation, migration, invasion, EMT, and inhibited apoptosis | AGAP2-AS1/miR-16-5p/ANXA11/AKT | [19] |
| Overexpression of AGAP2-AS1 increases HIF-1α expression |