Table 3.
Network meta-analysis of cytokines levels in COVID-19 patients with different clinical stages MD (95%CI)
| Comparisons | IL-1β (ng/L) | IL-6 (ng/L) | IL-10 (ng/L) | TNF-α (ng/L) |
|---|---|---|---|---|
| Severe VS. Mild a | 0.07 (−0.05, 0.20) | 25.70 (9.99, 41.41) | 1.42 (0.31, 2.54) | 0.28 (−2.41, 2.97) |
| Critical VS. Mild a | 0.15 (0.01, 0.30) | 56.90 (36.29, 77.52) | 3.93 (2.23, 5.63) | −0.11 (−3.49, 3.26) |
| Critical VS. Severe a | 0.08 (−0.10, 0.26) | 31.21 (10.59, 51.82) | 2.51 (0.54, 4.47) | −0.40 (−3.79, 3.00) |
| Inconsistency P-value | 0.545 | 0.408 | 0.510 | 0.993 |
aWhen comparing, the groups in the later positions were taken as the reference
Abbreviations: IL interleukin, TNF tumor necrosis factor