1. Drug regimens for heart failure and their effect on various circulating biomarkers.

Drug Biomarker	MRAs	ACEi	ARB	DRI	ARNI	BB	LD
ACEi: angiotensin converting enzyme inhibitors; ARB: angiotensin receptor blockers; ARNI: angiotensin receptor neprilysin inhibitor; BB: beta-blockers; BNP: brain natriuretic peptide; DRI: direct renin inhibitor; hs-CRP: high-sensitive C-reactive protein; LD: loop diuretics; MRAs: mineralocorticoid receptor antagonists; NT-proBNP: Amino-terminal fragment of proBNP.
BNP	↓	↓	↓	↓	↑	↑>↓	↓
NT-proBNP	↓	↓	↓	↓	↓	↑>↓	↓
Aldosterone	↕	↕	↕	↓/=	↓	↓	↑
Plasma renin activity	↑	↑	↑	↓	↑	↓	↑
Plasma renin concentration	?	↑	↑	↑	↑	↓	↑
Angiotensin I	?	↑	↑	↓	?	↓	↑
Angiotensin II	↑	↓	↑	↓	↑	↓	↑
hs-CRP	=	↓	↓	?	=	↓	=
Copeptin	↓	↓	↓	↓	?	↑>↓	↓
Galectin-3	=	=	=	?	=	=	=
Soluble suppression of tumorigenicity protein-2	?	↓	↓/=	?	=	↓	?
Growth differentiation factor-15	?	↓	=	?	?	↓?	?
Adrenomedullin	↓	↓?	↓?	↓?	?	↑>↓	↓