2. Crude and adjusted associations with all-cause mortality and HF after-discharge according to quartiles of electrolyte variability independent of the mean.

All-cause death (n = 4386)	Crude HR (95%CI)	P value	Model I HR (95%CI)	P value	Model II HR (95%CI)	P value	Model III HR(95%CI)	P value
Model I: adjusted for age and sex (n = 4386); Model II: adjusted for model 1 plus BMI, smoking, hypertension, diabetes, piror MI, cTnI, NTpro-BNP, CRP, eGFR, TG, TC, HDL, MI type, anterior MI, PCI, ACEI or ARB, spironolactone and acute heart failure (n = 4190). Model III: adjusted for model 1 plus mean potassium (n = 4190). ACEI: angiotensin-converting enzyme inhibitor; ARB: angiotensin receptor blocker; CI: confidence interval; cTnI: cardiac troponin I; CRP: C-reactive protein; eGFR: estimated glomerular filtration rate; HDL: high density lipoprotein; HF: heart failure; HR: hazards ratio; MI: myocardial infarction; NT-proBNP: N terminal pro B type natriuretic peptide; TC: total cholesterol; TG: triglycerides; PCI: percutaneous coronary intervention.
K range per 1 mmol/L	2.62 (2.10−3.27)	0.000	2.43(1.95−3.03)	0.000	1.69 (1.30−2.20)	0.000	1.68 (1.29−2.19)	0.000
Na range per 5 mmol/L	1.80 (1.54−2.10)	0.000	1.66 (1.42−1.94)	0.000	1.26 (1.05−1.50)	0.013	1.26 (1.05−1.51)	0.011
K VIM quartiles		0.000		0.000		0.004		0.003
Q1	1(ref.)		1(ref.)		1(ref.)		1(ref.)
Q2	2.19 (1.24−3.88)		2.11 (1.19−3.74)		1.69 (0.94−3.03)		1.69 (0.94−3.03)
Q3	2.41 (1.37−4.24)		2.36 (1.34−4.14)		1.59 (0.90−2.83)		1.59 (0.89−2.82)
Q4	3.52 (2.06−6.01)		3.59 (2.10−6.13)		2.30 (1.33−3.99)		2.35 (1.36−4.06)
Na VIM quartiles		0.000		0.003		0.416		0.348
Q1	1(ref.)		1(ref.)		1(ref.)		1(ref.)
Q2	1.27 (0.77−2.10)		1.18 (0.72−1.95)		0.93 (0.56−1.55)		0.94 (0.56−1.56)
Q3	1.53 (0.94−2.48)		1.39 (0.85−2.25)		1.01 (0.61−1.66)		1.02 (0.62−1.68)
Q4	2.24 (1.42−3.54)		1.91 (1.21−3.03)		1.16 (0.72−1.86)		1.19 (0.74−1.92)
HF after-discharge
K range per 1 mmol/L	1.93 (1.68−2.22)	0.000	1.86 (1.62−2.14)	0.000	1.26 (1.07−1.48)	0.005	1.27 (1.08−1.50)	0.004
Na range per 5 mmol/L	1.56 (1.42−1.72)	0.000	1.49 (1.36−1.64)	0.000	1.16 (1.04−1.29)	0.009	1.16 (1.04−1.30)	0.008
K VIM quartiles		0.000		0.000		0.051		0.051
Q1	1(ref.)		1(ref.)		1(ref.)		1(ref.)
Q2	1.48 (1.13−1.93)		1.45 (1.11−1.89)		1.22 (0.93−1.61)		1.22 (0.93−1.61)
Q3	1.73 (1.34−2.25)		1.72 (1.33−2.23)		1.27 (0.97−1.67)		1.27 (0.97−1.67)
Q4	1.99 (1.55−2.57)		2.02 (1.56−2.60)		1.32 (1.01−1.72)		1.32 (1.01−1.72)
Na VIM quartiles		0.000		0.000		0.040		0.038
Q1	1(ref.)		1(ref.)		1(ref.)		1(ref.)
Q2	1.26 (0.96−1.64)		1.21 (0.93−1.58)		1.01 (0.77−1.34)		1.02 (0.77−1.34)
Q3	1.58 (1.22−2.04)		1.51 (1.17−1.95)		1.17 (0.90−1.53)		1.18 (0.90−1.54)
Q4	2.03 (1.59−2.60)		1.87 (1.46−2.39)		1.25 (0.97−1.63)		1.26 (0.97−1.64)