Table 2.
The sevoflurane exposure (6 h)-induced dysregulated lncRNAs associated with neurological diseases and functions.
| Diseases or Functions Annotation | p-Value | mRNAs | Highly Correlated Co-Expressed lncRNAs |
|---|---|---|---|
| Apoptosis of granule cells | 0.00000606 | ADCYAP1, FAS, FRAT1, JUN, MECP2 | ENSMUST00000153752, uc012fts.1, AK084576, TCONS_00020793, ENSMUST00000169975, AK143771, TCONS_00020794, ENSMUST00000137546, ENSMUST00000135739, ENSMUST00000172524, uc007guo.1, uc012fts.1, ENSMUST00000155268, uc009mzl.1, mouselincRNA0733-, TCONS_00000533, ENSMUST00000117770, AK084576, AK032934, NR_024326, AK143771, AK167175, AK081961, AK030101, ENSMUST00000137546, mouselincRNA0733- NR_024257, AK131720, AV471140, AK143771, AK167175, AK081961, AK030101, ENSMUST00000137546, mouselincRNA0733- |
| Epileptic seizure | 0.000033 | ADCYAP1, CCR1, DUSP5, EGR4, HAS3, HSPB3, JUN, NR4A3 | ENSMUST00000153752, uc012fts.1,AK084576, ENSMUST00000145890, AK045892, NR_046157, AK131720, AK167175, ENSMUST00000134436, NR_024257, NR_036459, AK131720, uc009alp.2, ENSMUST00000126693, AK045957, AK086925, AV471140, ENSMUST00000155363, AK036595, AK014666, AK167175, ENSMUST00000145890, ENSMUST00000137546, AK045892, uc007uqa.1, NR_045190, NR_024257, ENSMUST00000169975, AK143771, ENSMUST00000137546, ENSMUST00000172524, uc007guo.1, uc012fts.1, mouselincRNA0733-, ENSMUST00000117770, AK084576, NR_045190, ENSMUST00000169975, AK143771, AK167175, AK081961, AK030101, ENSMUST00000137546, mouselincRNA0733-, ENSMUST00000169975, AK143771, TCONS_00020794, ENSMUST00000137546, ENSMUST00000135739, ENSMUST00000172524, uc012fts.1, uc009mzl.1, TCONS_00000533 |
| Epilepsy or neurodevelopmental disorder | 0.0000338 | ADCYAP1, AHNAK, BRPF1, CCR1, DUSP5, EGR4, GLI3, HAS3, HSPB3, JUN, MECP2, NR4A3, SCN11A | ENSMUST00000153752, uc012fts.1, AK084576, ENSMUST00000134436, NR_024257, NR_036459, AK131720, uc009alp.2, ENSMUST00000169975, AK045957, AK086925, AK143771, AK036595, AK167175, ENSMUST00000145890, ENSMUST00000137546, AK138866, NR_102396, uc007guo.1, mouselincRNA0733-, AK084576, NR_045190, AK081961, AK030101, NR_024326, ENSMUST00000145890, AK045892, NR_046157, AK131720, AK167175, ENSMUST00000134436, NR_024257, NR_036459, AK131720, uc009alp.2, ENSMUST00000126693, AK045957, AK086925, AV471140, ENSMUST00000155363, AK036595, AK014666, AK167175, ENSMUST00000145890, ENSMUST00000137546, AK045892, uc007uqa.1, NR_045190, ENSMUST00000135739, uc007guo.1, NR_024257, ENSMUST00000169975, AK143771, ENSMUST00000137546, ENSMUST00000172524, uc007guo.1, uc012fts.1, mouselincRNA0733-, ENSMUST00000117770, AK084576, NR_045190, ENSMUST00000169975, AK143771, AK167175, AK081961, AK030101, ENSMUST00000137546, mouselincRNA0733-, NR_024257, AK131720, AV471140, AK143771, AK167175, AK081961, AK030101, ENSMUST00000137546, mouselincRNA0733-, ENSMUST00000169975, AK143771, TCONS_00020794, ENSMUST00000137546, ENSMUST00000135739, ENSMUST00000172524, uc012fts.1, uc009mzl.1, TCONS_00000533, AK149342 |
| Epilepsy | 0.000035 | ADCYAP1, CCR1, DUSP5, EGR4, GLI3, HAS3, HSPB3, JUN, MECP2, NR4A3, SCN11A | ENSMUST00000153752, uc012fts.1, AK084576, ENSMUST00000145890, AK045892, NR_046157, AK131720, AK167175, ENSMUST00000134436, NR_024257, NR_036459, AK131720, uc009alp.2, ENSMUST00000126693, AK045957, AK086925, AV471140, ENSMUST00000155363, AK036595, AK014666, AK167175, ENSMUST00000145890, ENSMUST00000137546, AK045892, uc007uqa.1, NR_045190, ENSMUST00000135739, uc007guo.1, NR_024257, ENSMUST00000169975, AK143771, ENSMUST00000137546, ENSMUST00000172524, uc007guo.1, uc012fts.1, mouselincRNA0733-, ENSMUST00000117770, AK084576, NR_045190, ENSMUST00000169975, AK143771, AK167175, AK081961, AK030101, ENSMUST00000137546, mouselincRNA0733-, NR_024257, AK131720, AV471140, AK143771, AK167175, AK081961, AK030101, ENSMUST00000137546, mouselincRNA0733-, ENSMUST00000169975, AK143771, TCONS_00020794, ENSMUST00000137546, ENSMUST00000135739, ENSMUST00000172524, uc012fts.1, uc009mzl.1, TCONS_00000533, AK149342 |
| Apoptosis of cerebellar granule cell | 0.000134 | FRAT1, JUN, MECP2 | NR_024326, AK143771, AK167175, AK081961, AK030101, ENSMUST00000137546, mouselincRNA0733-,NR_024257, AK131720, AV471140, AK143771, AK167175, AK081961, AK030101, ENSMUST00000137546, mouselincRNA0733- |
| Cell death of cerebellar cortex cells | 0.000174 | FAS, FRAT1, JUN, MECP2 | TCONS_00020793, ENSMUST00000169975, AK143771, TCONS_00020794, ENSMUST00000137546, ENSMUST00000135739, ENSMUST00000172524, uc007guo.1, uc012fts.1, ENSMUST00000155268, uc009mzl.1, mouselincRNA0733-, TCONS_00000533, ENSMUST00000117770, AK084576, AK032934, NR_024326, AK143771, AK167175, AK081961, AK030101, ENSMUST00000137546, mouselincRNA0733-, NR_024257, AK131720, AV471140, AK143771, AK167175, AK081961, AK030101, ENSMUST00000137546, mouselincRNA0733- |
| Apoptosis of brain cells | 0.00022 | ADCYAP1, ALOX15, FAS, FRAT1, JUN, MECP2 | ENSMUST00000153752, uc012fts.1, AK084576, AK131720, uc009alp.2, AK045957, AV471140, ENSMUST00000155363, AK036595, AK167175, AK081961, ENSMUST00000137546, mouselincRNA0733-, TCONS_00020793, ENSMUST00000169975, AK143771, TCONS_00020794, ENSMUST00000137546, ENSMUST00000135739, ENSMUST00000172524, uc007guo.1, uc012fts.1, ENSMUST00000155268, uc009mzl.1, mouselincRNA0733-, TCONS_00000533, ENSMUST00000117770, AK084576, AK032934, NR_024326, AK143771, AK167175, AK081961, AK030101, ENSMUST00000137546, mouselincRNA0733-, NR_024257, AK131720, AV471140, AK143771, AK167175, AK081961, AK030101, ENSMUST00000137546, mouselincRNA0733- |
| Seizure disorder | 0.000386 | ADCYAP1, CCR1,DUSP5, EGR4, GLI3, HAS3, HSPB3, JUN, MECP2, NR4A3, SCN11A, ST8SIA4 | ENSMUST00000153752, uc012fts.1, AK084576, ENSMUST00000145890, AK045892, NR_046157, AK131720, AK167175, ENSMUST00000134436, NR_024257, NR_036459, AK131720, uc009alp.2, ENSMUST00000126693, AK045957, AK086925, AV471140, ENSMUST00000155363, AK036595, AK014666, AK167175, ENSMUST00000145890, ENSMUST00000137546, AK045892, uc007uqa.1, NR_045190, ENSMUST00000135739, uc007guo.1, NR_024257, ENSMUST00000169975, AK143771, ENSMUST00000137546, ENSMUST00000172524, uc007guo.1, uc012fts.1, mouselincRNA0733-, ENSMUST00000117770, AK084576, NR_045190, ENSMUST00000169975 AK143771, AK167175, AK081961, AK030101, ENSMUST00000137546, mouselincRNA0733-, NR_024257, AK131720, AV471140, AK143771, AK167175, AK081961, AK030101, ENSMUST00000137546, mouselincRNA0733-, ENSMUST00000169975, AK143771, TCONS_00020794, ENSMUST00000137546, ENSMUST00000135739, ENSMUST00000172524, uc012fts.1, uc009mzl.1, TCONS_00000533, AK149342, ENSMUST00000118347, TCONS_00020794 |
| Seizures | 0.000487 | ADCYAP1, CCR1, DUSP5, EGR4, HAS3, HSPB3, JUN, MECP2, NR4A3, SCN11A, ST8SIA4 | ENSMUST00000153752, uc012fts.1, AK084576, ENSMUST00000145890, AK045892, NR_046157, AK131720, AK167175, ENSMUST00000134436, NR_024257, NR_036459, AK131720, uc009alp.2, ENSMUST00000126693, AK045957, AK086925, AV471140, ENSMUST00000155363, AK036595, AK014666, AK167175, ENSMUST00000145890, ENSMUST00000137546, AK045892, uc007uqa.1, NR_045190, NR_024257, ENSMUST00000169975, AK143771, ENSMUST00000137546, ENSMUST00000172524, uc007guo.1, uc012fts.1, mouselincRNA0733-, ENSMUST00000117770, AK084576, NR_045190, ENSMUST00000169975, AK143771, AK167175, AK081961, AK030101, ENSMUST00000137546, mouselincRNA0733-, NR_024257, AK131720, AV471140, AK143771, AK167175, AK081961, AK030101, ENSMUST00000137546, mouselincRNA0733-, ENSMUST00000169975, AK143771, TCONS_00020794, ENSMUST00000137546, ENSMUST00000135739, ENSMUST00000172524, uc012fts.1, uc009mzl.1, TCONS_00000533, AK149342, ENSMUST00000118347, TCONS_00020794 |
| Apoptosis of cortical neurons | 0.00153 | ALOX15, FAS, JUN, MECP2 | AK131720, uc009alp.2, AK045957, AV471140, ENSMUST00000155363, AK036595, AK167175, AK081961, ENSMUST00000137546, mouselincRNA0733-, TCONS_00020793, ENSMUST00000169975, AK143771, TCONS_00020794, ENSMUST00000137546, ENSMUST00000135739, ENSMUST00000172524, uc007guo.1, uc012fts.1, ENSMUST00000155268, uc009mzl.1, mouselincRNA0733-, TCONS_00000533, ENSMUST00000117770, AK084576, AK032934, AK143771, AK167175, AK081961, AK030101, ENSMUST00000137546, mouselincRNA0733-, NR_024257, AK131720, AV471140, AK143771, AK167175, AK081961, AK030101, ENSMUST00000137546, mouselincRNA0733- |
| Hereditary sensory and autonomic neuropathy type VII | 0.00479 | SCN11A | AK149342 |
| Zappella variant Rett syndrome | 0.00479 | MECP2 | NR_024257, AK131720, AV471140, AK143771, AK167175, AK081961, AK030101, ENSMUST00000137546, mouselincRNA0733- |
| Blepharophimosis, ptosis, and epicanthus inversus type II with Duane retraction syndrome | 0.00479 | FOXL2 | TCONS_00020793, TCONS_00020794, ENSMUST00000135739, ENSMUST00000172524, uc007guo.1, ENSMUST00000153752, uc012fts.1, ENSMUST00000155268, TCONS_00000533, AK032934 |
| Kallmann syndrome type 17 | 0.00479 | SPRY4 | ENSMUST00000134436, AK131720, uc009alp.2, ENSMUST00000169975, AK045957, AK086925, AK143771, AK036595, ENSMUST00000145890, ENSMUST00000137546, AK138866, uc007guo.1, uc012fts.1, mouselincRNA0733-, ENSMUST00000117770, AK084576, NR_045190 |
| Susceptibility to X-linked autism type 3 | 0.00479 | MECP2 | NR_024257, AK131720, AV471140, AK143771, AK167175, AK081961, AK030101, ENSMUST00000137546, mouselincRNA0733- |
| Distal hereditary motor neuronopathy type IIC | 0.00479 | HSPB3 | ENSMUST00000169975 |
| Susceptibility to hypogonadotropic hypogonadism type 17 | 0.00479 | SPRY4 | ENSMUST00000134436, AK131720, uc009alp.2, ENSMUST00000169975, AK045957, AK086925, AK143771, AK036595, ENSMUST00000145890, ENSMUST00000137546, AK138866, uc007guo.1, uc012fts.1, mouselincRNA0733-, ENSMUST00000117770, AK084576, NR_045190 |
| Neurodegeneration of sympathetic neuron | 0.00479 | JUN | AK143771, AK167175, AK081961, AK030101, ENSMUST00000137546, mouselincRNA0733- |
| Hypogonadotropic hypogonadism 17 without anosmia | 0.00479 | SPRY4 | ENSMUST00000134436, AK131720, uc009alp.2, ENSMUST00000169975, AK045957, AK086925, AK143771, AK036595, ENSMUST00000145890, ENSMUST00000137546, AK138866, uc007guo.1, uc012fts.1, mouselincRNA0733-, ENSMUST00000117770, AK084576, NR_045190 |
| X-linked mental retardation syndromic 13 | 0.00479 | MECP2 | NR_024257, AK131720, AV471140, AK143771, AK167175, AK081961, AK030101, ENSMUST00000137546, mouselincRNA0733- |
| Neonatal severe encephalopathy | 0.00479 | MECP2 | NR_024257, AK131720, AV471140, AK143771, AK167175, AK081961, AK030101, ENSMUST00000137546, mouselincRNA0733- |
| Intellectual developmental disorder with dysmorphic facies and ptosis | 0.00479 | BRPF1 | AK081961, AK030101, NR_024326 |
| Degeneration of cholinergic fibers | 0.00479 | JUN | AK143771, AK167175, AK081961, AK030101, ENSMUST00000137546, mouselincRNA0733- |
| Autosomal recessive intellectual developmental disorder 68 | 0.00479 | TRMT1 | AK143771, TCONS_00020794, uc012fts.1, ENSMUST00000155268, TCONS_00000533, ENSMUST00000117770, AK032934 |
| Familial episodic pain syndrome type 3 | 0.00479 | SCN11A | AK149342 |
| Lubs X-linked mental retardation syndrome | 0.00479 | MECP2 | NR_024257, AK131720, AV471140, AK143771, AK167175, AK081961, AK030101, ENSMUST00000137546, mouselincRNA0733- |
| Hypothalamic hamartoma | 0.00479 | GLI3 | ENSMUST00000135739, uc007guo.1 |
| Anosmia | 0.00908 | SLC7A11, SPRY4 | ENSMUST00000141521, ENSMUST00000135739, uc007guo.1, ENSMUST00000117770, AK032934, ENSMUST00000134436, AK131720, uc009alp.2, ENSMUST00000169975, AK045957, AK086925, AK143771, AK036595, ENSMUST00000145890, ENSMUST00000137546, AK138866, uc007guo.1, uc012fts.1, mouselincRNA0733-, ENSMUST00000117770, AK084576, NR_045190 |
| Lack of inferior colliculus | 0.00957 | GLI3 | ENSMUST00000135739, uc007guo.1 |
| Apoptosis of somatotrophs | 0.00957 | FAS | TCONS_00020793, ENSMUST00000169975, AK143771, TCONS_00020794, ENSMUST00000137546, ENSMUST00000135739, ENSMUST00000172524, uc007guo.1, uc012fts.1, ENSMUST00000155268, uc009mzl.1, mouselincRNA0733-, TCONS_00000533, ENSMUST00000117770, AK084576, AK032934 |
| Neurodegeneration of substantia nigra pars compacta | 0.00957 | SLC7A11 | ENSMUST00000141521, ENSMUST00000135739, uc007guo.1, ENSMUST00000117770, AK032934 |
| Familial Angelman syndrome | 0.00957 | MECP2 | NR_024257, AK131720, AV471140, AK143771, AK167175, AK081961, AK030101, ENSMUST00000137546, mouselincRNA0733- |
| Misrouting of thalamocortical axons | 0.00957 | ST8SIA4 | ENSMUST00000118347, TCONS_00020794 |
| Apoptosis of lactotropes | 0.00957 | FAS | TCONS_00020793, ENSMUST00000169975, AK143771, TCONS_00020794, ENSMUST00000137546, ENSMUST00000135739, ENSMUST00000172524, uc007guo.1, uc012fts.1, ENSMUST00000155268, uc009mzl.1, mouselincRNA0733-, TCONS_00000533, ENSMUST00000117770, AK084576, AK032934 |
Note: The full gene names of the sevoflurane-induced dysregulated mRNAs and lncRNAs are detailed in Supplementary Table S3.