Table 2.

Sickling Inhibition, Hb-O₂ Affinity, and Hb-Modification Studies Using SS RBCs with the Seven Compounds

	% sickling inhibition			% Hb-O2 affinity			% Hb-modification
compd	0.5 mM	1 mM	2 mM	0.5 mM	1 mM	2 mM	0.5 mM	1 mM	2 mM
2	41.8 ± 0.7	71.7 ± 0.9	99 ± 2.6	5.9 ± 0.7	12.8 ± 1.9	21.3 ± 2.1	32.1 ± 0.5	49.9 ± 1.6	67.5 ± 2.2
3	17.5 ± 1.1	48.2 ± 1.2	88 ± 5.5	4.8 ± 2.1	20.1 ± 1.3	37.1 ± 2.5	20.9 ± 1.5	41.7 ± 1.8	63.8 ± 3.2
5	37.6 ± 0.9	97.7 ± 1.5	99.1 ± 1.1	4.4 ± 0.9	13.9 ± 1.5	25.4 ± 1.1	30.2 ± 0.5	62.3 ± 1.9	79.2 ± 0.6
6	29.1 ± 1.2	81.6 ± 1.8	96.5 ± 0.7	9.9 ± 0.7	19.5 ± 0.8	32.3 ± 0.7	36.1 ± 1.1	64 ± 1.3	81.3 ± 1.4
9	43.3 ± 4.1	70.6 ± 4.1	98.8 ± 1.8	12.2 ± 2.1	18.8 ± 2.1	39.6 ± 1.3	46 ± 3.2	64.4 ± 2.7	90.8 ± 1.2
10	7.6 ± 1.1	54.2 ± 0.1	93.2 ± 4.4	5.4 ± 1.4	29.2 ± 1.1	48.6 ± 0.4	29.2 ± 1.6	81.1 ± 0.6	100 ± 0.7
13	39.5 ± 12	90.7 ± 11	98.9 ± 2.1	16.3 ± 12	44.2 ± 1.6	60.1 ± 2.1	47.8 ± 4.6	92.5 ± 5	100 ± 1.1