Table 3.
Significant correlations of radiomics features with gene expression levels in 48 HCCs
| Gene | Feature type | Feature names | r | FDR-adj p |
|---|---|---|---|---|
| IQGAP1 | Texture features | LAP information measure of correlation 116 bins | −0.44 | 0.031 |
| RAB31 | Texture features | LAP information measure of correlation 116 bins | −0.48 | 0.027 |
| CD37 | Texture features | Pre information measure of correlation 116 bins | −0.42 | 0.036 |
| POSTN | Texture features | LAP energy 16 bins | 0.45 | 0.043 |
| LAP entropy 16 bins | −0.55 | 0.011 | ||
| LAP information measure of correlation 116 bins | −0.45 | 0.030 | ||
| Qualitative features | Mosaic appearance | −0.47 | 0.036 | |
| ALOX5AP | Texture features | Pre information measure of correlation 116 bins | −0.46 | 0.028 |
| Pre information measure of correlation 2 16 bins | 0.47 | 0.028 | ||
| LAP entropy 16 bins | −0.46 | 0.039 | ||
| LAP information measure of correlation 116 bins | −0.48 | 0.027 | ||
| LAPTM5 | Texture features | Pre information measure of correlation 116 bins | −0.46 | 0.028 |
| Pre information measure of correlation 2 16 bins | 0.46 | 0.028 | ||
| LAP information measure of correlation 116 bins | −0.42 | 0.036 | ||
| CSPG2 | Texture features | Pre information measure of correlation 116 bins | −0.42 | 0.036 |
| LAP energy 16 bins | 0.50 | 0.028 | ||
| LAP entropy 16 bins | −0.52 | 0.017 | ||
| LAP information measure of correlation 116 bins | −0.46 | 0.030 | ||
| AFP | Quantitative features | ER HBP | 0.56 | 0.025 |
| TARBP1 | Texture features | EAP variance 16 bins | −0.61 | 0.013 |
| EAP variance 64 bins | −0.57 | 0.035 | ||
| GLYAT | Texture features | ADC maximal correlation 16 bins | −0.54 | 0.009 |
| MTHFD1 | Texture features | PVP maximal correlation 64 bins | 0.56 | 0.002 |
| DPAGT1 | Texture features | LAP energy 16 bins | 0.47 | 0.037 |
| PD1 | Texture features | LAP information measure of correlation 116 bins | −0.43 | 0.032 |
| CTLA4 | Texture features | LAP energy 16 bins | 0.47 | 0.037 |
| LAP information measure of correlation 116 bins | −0.48 | 0.027 |
Only genes for which significant correlations were found are shown. Correlation coefficient coefficients (r) resulted from Spearman correlation analysis. P values were adjusted for multiple tests using a false discovery rate (FDR) adjustment
ADC = apparent diffusion coefficient, EAP = early arterial phase, ER = enhancement ratio, HBP = hepatobiliary phase, LAP = late arterial phase, PVP = portal venous phase