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. 2021 Jan 25;11:597772. doi: 10.3389/fphar.2020.597772

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Copyright © 2021 Wang, Tu, Gao, Li, LI, Li, Zhao, Li, Liuchang, Pang, Cui, Ma and Xiao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathological damage in rats liver given LPS, emodin only and cotreated with LPS/emodin. (A) Liver sections from rats were treated with vehicle (0.5% CMC-Na); (B) with LPS (2.8 mg/kg); (C) emodin (20 mg/kg); (D) emodin (40 mg/kg); (E) emodin (80 mg/kg); (F) LPS/emodin (20 mg/kg); (G) LPS/emodin (40 mg/kg); (H) LPS/emodin (80 mg/kg). Liver samples were collected at 7 h after LPS tail intravenously injection (HE stained, ×200 magnification) and HE staining was performed to investigate the histological changes in all experimental groups.