Table 4.

Bioactive compounds from soil microbes and their applications

Soil type	Microorganisms	Bioactive compound(s)	Applications	References
Mangrove soil	Nocardiopsis alba	(Z)-1-((1-hydroxypenta-2,4-dien1-yl) oxy) anthracene-9,10-dione	Inhibit growth of many bacteria	[93]
All soil types containing actinomycetes	Streptomyces albolongus	K-252-C-Aglycone, indolocarbazole alkaloid, decoyinine, cycloheximide	Not yet explored	[94]
All soil types containing actinomycetes	Streptomyces enissocaesilis	Daunorubicin, hygromycin B, agecorynin F, indinavir-N-glucuronide and minocycline	Not yet explored	[94]
Mountain forest	Streptomyces sp. HW-003	AMRSA1	Anti-MRSA (Methicillin-resistant Staphylococcus aureus)	[95]
Desert soil	Streptomyces sp. C34	Chaxamycins	Anti-MRSA (Methicillin-resistant Staphylococcus aureus)	[96]
Mangrove forest soil	Microbacterium mangrovi MUSC 115	Methyllaurate, 2,4-di-tert-butyl phenol,(3R,8aS)-3-methyl-1,2,3,4,6,7,8,8a-octahydropyrrolo[1,2- a]pyrazine-1,4-dione, Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-, 1,4-diaza-2,5-dioxo-3-isobutyl bicyclo[4.3.0]nonane, and 3-benzyl-1,4-diaza-2,5-dioxobicyclo[4.3.0]nonane	Antibacterial, anticancer and neuroprotective activities	[97]
Mangrove forest soil	Sinomonas humi MUSC 117	Butanoic acid, 3-methyl-, Butanoic acid, 2-methyl-, 2,4-di-tert-butyl phenol, (3R,8aS)-3-Methyl-1,2,3,4,6,7,8,8a-octahydropyrrolo[1,2- a]pyrazine-1,4-dione, Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-, Methyl n-pentadecanoate, 1,4-diaza-2,5-dioxo-3-isobutyl bicyclo[4.3.0]nonane, 5,10-Diethoxy-2,3,7,8-tetrahydro-1H,6H-dipyrrolo[1,2- a:10,20 -d]pyrazine, Methyl 14-methylhexadecanoate, and pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3- (phenylmethyl)-	Antibacterial, anticancer and neuroprotective activities	[97]
Mangrove forest soil	Monashia flava MUSC 78	2-Methylpyrazine; Pyrrole, 2-methyl-; Pyrazine, 2,5-dimethyl-; 2,3,4-Trithiapentane; Pyrazine, 2-ethyl-6-methyl-; Pyrazine, 2-ethyl-5-methyl-; Pyrazine, trimethyl-; Pyrazine, 3-ethyl-2,5-dimethyl-; 4H-Pyran-4-one, 3-hydroxy-2-methyl-; 1H-Indole, 2,4-di-tert-butyl phenol; 1H-Pyrrole, 2-phenyl-, 1-Naphthalenamine, N-ethyl-; 3,4-Dimethyl-2-phenyl-1H-pyrrole; (3R,8aS)-3-Methyl-1,2,3,4,6,7,8,8a-octahydropyrrolo[1,2- a]pyrazine-1,4-dione; Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-; Methyl 13-methyltetradecanoate; Hexadecanoic acid, methyl ester; Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(2- methylpropyl); 3-benzyl-1,4-diaza-2,5-dioxobicyclo[4.3.0]nonane	Antibacterial, anticancer and neuroprotective activities	[97]
Deep sea	Nesterenkonia flava MCCC 1K00610	Macrolactin A; macrolactin F; cyclo(D)-Pro-(D)-Leu; cyclo-(Leu-Thr); thymidine; 2′-O-methyluridine; indol-3-carbaldehyde; 2-(1H-indol-3-yl)ethan-1-ol; 2-hydroxy phenyl acetic acid; 4-(hydroxymethyl)phenol; 2-(4-hydroxyphenyl)-ethanol; and 2,3-butanediol	Anti-allergic activities	[98]
Different soil types	Streptomyces thermolilacinus	Not yet explored	Antagonistic activities against MDR pathogens	[99]
Rhizosphere soil	Streptomyces lilacinus NRRL B-1968 T	2,4-bis (1,1-dimethylethyl)-phenol; 1-hexadecene; tetradecanoic acid; (E)-9-eicosene; pentadecanoic acid; i-propyl 12-methyltetradecanoate; N-hexadecanoic acid; (10Z)-4,9,13-triacetoxy-3,6,6,10,14-pentamethyl-2-oxo-16-oxatetracyclo [10.3.1.01,12.05,7] hexadec-10-en-8-yl nicotinate; 2-(3-acetoxy-4,4,14-trimethylandrost-8-en-17-yl)-propanoic acid; heptadecanoic acid; 3-hydroxy-2-tetradecyl-octadecanoic acid methyl ester; oleic acid; octadecanoic acid; octadecanoic acid, 2-hydroxy-1,3-propanediyl ester; hexahydro-3-(phenylmethyl) pyrrolo[1,2-a]pyrazine-1,4-dione; hexadecanoic acid, 2,3-dihydroxypropyl ester; bis(2-ethylhexyl) phthalate; trans-11-eicosenamide; (Z)-13-docosenamide; olean-13 (18) ene; and pentacyclo[19.3.1.1(3,7).1(9,13).1(15,19)]octacosa-1(25),3,5,7(28), 9,11,13(27),15,17,19(26),21,23-dodecaene-25,26,27,28-tetrol, 5, 11,17,23-tetrakis (1,1-dimethylethyl)	Antimicrobial and other biological activities	[100]
Forest soils	Brevibacterium sp	Antibiofilm and cytotoxic compounds	Antibiotic resistance and chromium tolerance abilities	[101]
Rhizosphere soil	Streptomyces triticiradicis sp.	3-Acetylamino-N-2-thienyl-propanamide; 2,3-dihydroxybutanone; ß-adenosine and 2-minaline	Antifungal activity	[102]