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. 2021 Feb 8;14:38. doi: 10.1186/s13068-021-01885-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Ume6p mediates the effect of HYP2 overexpression on yeast cells response to acetic acid. a Direct targets of Ume6p involved in acetic acid response. The log2 values of relative transcription levels were compared. (1) Genes involved in chromatin remodeling, transcription and RNA processing. (2) Genes involved in protein modification, trafficking and sorting. (3) Genes involved in mitochondrial function. (4) Genes involved in carbohydrate metabolism. (5) Gene involved in remodeling and maintaining cell wall architecture. (6) Unknown function. b Transcription levels of Ume6p direct targets. c Effect of Ume6p activity on cell growth upon acetic acid stress. d Effect of Ume6p activity on transcription of BEM4, BUD21 and IME4. Yeast cells were cultured under conditions with or without 87 mM acetic acid (pH 4.2) for 4 h. The relative transcription of target gene in YS58-V under non-stressed condition was defined as a value of 1, respectively. Data are presented as the means of the results of three independent experiments. Error bars represent standard deviations (*P < 0.05, **P < 0.01)