Table 2.

Studies on role of laser interstitial thermal therapy in metastatic tumors

Study	Number of patients	Reported outcomes/complications	System used
Carpienter et al., 2008[32]	4 (6 lesions)	Gradual and steady decrease in lesion volume with no tumor recurrence within thermal ablation zones	Visualase system
Carpienter et al., 2011[33]	7 (15 lesions)	Mean OS: 17.4+/-3.5 months. Mean PFS: 3.8+/-1.0 months. No major complications noted.	Visualase system
Hawasli et al., 2013[24]	5 (Mets)	Median OS: 5.8 months. Two patients had transient postoperative deficits	Neuroblate system
Ali et al., 2016[35]	23	Lesions in which <80% ablation was achieved, 35% of these progressed	Visualase and neuroblate system
		Complications: Three patients had transient hemiparesis, one developed hydrocephalus, and one required emergency hemicraniectomy
Chaunzwa et al., 2017[34]	30	OS: 52.3% at 6 months, 26.1% at 12 months, 21.8% at 18 months, and 16.3% at 30 months	Neuroblate system

PFS – Progression-free survival; OS – Overall survival