. 2021 Jan 29;2021:6622437. doi: 10.1155/2021/6622437

Table 3.

Correlation analysis between CDCA3 and related genes and markers of immune cells in TIMER.

Description	Gene markers	HCC
		None		Purity
		Partial cor	p value	Partial cor	p value
CD8+ T cell	CD8A	0.189	∗∗∗	0.294	∗∗∗
CD8+ T cell	CD8B	0.225	∗∗∗	0.326	∗∗∗
T cell (general)	CD3D	0.318	∗∗∗	0.435	∗∗∗
	CD3E	0.194	∗∗	0.344	∗∗∗
	CD2	0.209	∗∗∗	0.347	∗∗∗
B cell	CD19	0.243	∗∗∗	0.319	∗∗∗
B cell	CD79A	0.154	∗	0.266	∗∗∗
Monocyte	CD86	0.259	∗∗∗	0.395	∗∗∗
Monocyte	CD115	0.109	0.0366	0.228	∗∗∗
TAM	CCL2	-0.001	0.979	0.079	0.141
	CD68	0.208	∗∗∗	0.288	∗∗∗
	IL10	0.182	∗∗	0.281	∗∗∗
M1 macrophage	iNOS	0.226	∗∗∗	0.274	∗∗∗
	IRF5	0.362	∗∗∗	0.372	∗∗∗
	COX2	-0.009	0.86	0.089	0.0996
M2 macrophage	CD163	-0.004	0.935	0.077	0.154
	VSIG4	0.035	0.498	0.117	0.0303
	MS4A4A	0.023	0.656	0.125	0.0201
Neutrophils	CD66b	0.102	0.05	0.126	0.0189
	CD11b	0.243	∗∗∗	0.32	∗∗∗
	CCR7	0.036	0.493	0.163	∗
Natural killer cell	KIR2DL1	-0.023	0.665	-0.036	0.504
	KIR2DL3	-0.158	∗	0.2	∗∗
	KIR2DL4	0.216	∗∗∗	0.247	∗∗∗
	KIR3DL1	-0.008	0.88	0.005	0.924
	KIR3DL2	0.095	0.0662	0.129	0.0162
	KIR3DL3	0.076	0.143	0.097	0.0728
	KIR2DS4	0.051	0.332	0.046	0.398
Dendritic cell	HLA-DPB1	0.143	∗	0.25	∗∗∗
	HLA-DQB1	0.147	∗	0.245	∗∗∗
	HLA-DRA	0.131	0.0117	0.236	∗∗∗
	HLA-DPA1	0.095	0.0684	0.203	∗∗
	BDCA-1	0.071	0.175	0.159	∗
	BDCA-4	0.121	0.0199	0.141	∗
	CD11c	0.285	∗∗∗	0.408	∗∗∗
Th1	T-bet	0.069	0.185	0.175	∗
	STAT4	0.21	∗∗∗	0.271	∗∗∗
	STAT1	0.286	∗∗∗	0.335	∗∗∗
	IFN-γ	0.278	∗∗∗	0.353	∗∗∗
	TNF-α	0.216	∗∗∗	0.34	∗∗∗
Th2	GATA3	0.155	∗	0.274	∗∗∗
	STAT6	0.005	0.926	0.005	0.931
	STAT5A	0.212	∗∗∗	0.254	∗∗∗
	IL13	0.084	0.107	0.094	0.0807
Tfh	BCL6	0.071	0.172	0.075	0.163
Tfh	IL21	0.129	0.0132	0.171	∗
Th17	STAT3	-0.023	0.657	0.003	0.963
Th17	IL17A	0.081	0.12	0.1	0.0639
Treg	FOXP3	0.094	0.0713	0.174	∗
	CCR8	0.27	∗∗∗	0.352	∗∗∗
	STAT5B	0.092	0.0763	0.077	0.155
	TGFβ (TGFB1)	0.259	∗∗∗	0.351	∗∗∗
Exhausted T cells	PD-1 (PDCD-1)	0.347	∗∗∗	0.454	∗∗∗
	CTLA4	0.362	∗∗∗	0.474	∗∗∗
	LAG3	0.364	∗∗∗	0.415	∗∗∗
	TIM3 (HAVCR2)	0.284	∗∗∗	0.427	∗∗∗
	GZMB	0.111	0.0327	0.186	∗∗

HCC: hepatocellular carcinoma; TAM: tumor-associated macrophage; Th1: T-helper 1 cells; Th2: T-helper 2 cells; Th17: T-helper 17 cells; Tfh: follicular helper T cell; Treg: regulatory T cell. Note: partial cor (partial correlation coefficient) represents the correlation coefficient between the CDCA3 expression and gene markers of infiltrating immune cells; purity represents the correlation adjusted by purity; none represents the correlation without adjustment; ^∗p < 0.01, ^∗∗p < 0.001, and ^∗∗∗p < 0.0001.