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. Author manuscript; available in PMC: 2021 Feb 8.
Published in final edited form as: Neuroimage. 2020 Oct 27;225:117509. doi: 10.1016/j.neuroimage.2020.117509

Fig. 2. tNAA relates to emotional flexibility and resilience to aggression.

Fig. 2.

(A) tNAA in the dACC is strongly positively related to scores on trait Absorption, r = + 0.56, unadjusted p =.005, R2 = 0.31. The finding is large in size and survived correction using the Holm-Bonferroni sequential method (Holm adjusted p = .0324; family-wise α = 0.05). (B) tNAA in the dACC is positively related to scores on trait Social Potency, r = + 0.42, unadjusted p = .03, R2 = 0.17. The finding did not survive correction using the Holm-Bonferroni sequential method (Holm adjusted p = .167; family-wise α = 0.05), and thus is considered preliminary. (C) tNAA in the dACC is strongly negatively related to trait scores on trait Aggression, r = − 0.59, unadjusted p =.003, R2 = 0.35. The finding is large in size and survived correction using the Holm-Bonferroni sequential method (Holm adjusted p = .0210; family-wise α = 0.05).

tNAA = total N-acetyl-aspartate and N-acetylaspartylglutamate, corrected for partial volume effects. dACC = dorsal anterior cingulate; voxel size was 15 × 15 × 10 mm (10 mm in SI direction; see Methods for details). Personality was evaluated using the Multidimensional Personality Questionnaire Brief Form (MPQ-BF). gray shading is 95% confidence interval.

N = 20 participants with 1 H MRS data meeting quality control criteria; see Methods section for details.