TABLE 2.

Replication in independent cohorts in a study of genetic risk loci for anxiety^a

			GAD-2 MVP European American Meta-Analysisb		iPSYCH Anxiety and Stress-Related Disorders (9)		UK Biobank, 23andMe, and GPC Neuroticism (31)		ANGST Anxiety (8)
RSID	CHR	Gene	p	Risk Allele	p	Risk Allele	p	Risk Allele	p	Risk Allele
rs4603973	3	SATB1-AS1	6.18E–11	G	0.181	G	na	na	0.0299	G
rs4390955	3	SATB1-AS1	7.78E–11	A	0.851	C	5.20E–04	A	0.2935	A
rs6557168	6	ESR1	1.33E–09	C	0.0128	C	0.367	C	0.170	C
rs12023347	1	LINC01360 /LRRIQ3	8.88E–09	T	6.61E–04	T	6.85E–04	T	0.00296	T
rs56226325	7	MAD1L1	2.01E–08	C	6.41E–04	C	6.59E–08	C	0.354	C
rs6090040	20	TCEA2	3.28E–08	C	0.461	A	0.444	A	0.867	C

^aItalic font indicates same direction of effect, and boldface indicates same direction of effect and nominal significance (p=0.05). The lead SNP on chromosome 3 near the SATB1 locus, rs4603973, was not available for lookup in the UK Biobank neuroticism genome-wide association study, so we used the strongest LD proxy available (rs4390955, R²=0.91, p=7.78E–11). ANGST=Anxiety Neuro Genetics Study; CHR=chromosome; GAD-2=Generalized Anxiety Disorder 2-item scale; GPC=Genetics of Personality Consortium; iPSYCH=Initiative for Integrative Psychiatric Research; MVP=Million Veteran Program; RSID=reference SNP cluster ID.

^bResults from the present study.